Literature DB >> 21603337

Use of α(2)-Agonists in Neuroanesthesia: An Overview.

Ehab Farag, Maged Argalious, Daniel I Sessler, Andrea Kurz, Zeyd Y Ebrahim, Armin Schubert.   

Abstract

α(2)-Agonists are a novel class of drugs with mechanisms of action that differ from other commonly used anesthetic drugs. They have neuroprotective, cardioprotective, and sedative effects. These unique characteristics make them potentially useful during neuroanesthesia and intensive care. We review the effects of dexmedetomidine on cerebral blood flow and cerebral metabolism, along with recent advances in using α(2)-agonists in neuroanesthesia and neurointensive care.

Entities:  

Keywords:  Alpha-2 agonist; anesthesia; dexmedetomidine; neuroanesthesia; neuroprotection

Year:  2011        PMID： 21603337      PMCID： PMC3096156     

Source DB:  PubMed          Journal:  Ochsner J        ISSN： 1524-5012


  84 in total

1.  Pial arteriolar constriction to alpha 2-adrenergic agonist dexmedetomidine in the rat.

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Journal:  Am J Physiol       Date:  1997-06

2.  Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions.

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3.  Dexmedetomidine sedation during awake craniotomy for seizure resection: effects on electrocorticography.

Authors:  Michael J Souter; Irene Rozet; Jeffrey G Ojemann; Karen J Souter; Mark D Holmes; Lorri Lee; Arthur M Lam
Journal:  J Neurosurg Anesthesiol       Date:  2007-01       Impact factor: 3.956

4.  Clinical experience with dexmedetomidine for implantation of deep brain stimulators in Parkinson's disease.

Authors:  Irene Rozet; Saipin Muangman; Monica S Vavilala; Lorri A Lee; Michael J Souter; Karen J Domino; Jefferson C Slimp; Robert Goodkin; Arthur M Lam
Journal:  Anesth Analg       Date:  2006-11       Impact factor: 5.108

5.  A pilot study of topical treatment with an alpha2-agonist in patients with retinal dystrophies.

Authors:  Saul Merin; Alexey Obolensky; Marilyn D Farber; Itay Chowers
Journal:  J Ocul Pharmacol Ther       Date:  2008-02       Impact factor: 2.671

6.  Attentional effects of noradrenaline vary with arousal level: selective activation of thalamic pulvinar in humans.

Authors:  Jennifer T Coull; Matt E P Jones; Talmage D Egan; Chris D Frith; Mervyn Maze
Journal:  Neuroimage       Date:  2004-05       Impact factor: 6.556

7.  Dexmedetomidine attenuates the hemodynamic and neuroendocrinal responses to skull-pin head-holder application during craniotomy.

Authors:  Ahmet Senol Uyar; Hatice Yagmurdur; Yasemin Fidan; Cigdem Topkaya; Hulya Basar
Journal:  J Neurosurg Anesthesiol       Date:  2008-07       Impact factor: 3.956

8.  Comparative effects of propofol vs dexmedetomidine on cerebrovascular carbon dioxide reactivity in patients with septic shock.

Authors:  Y Kadoi; S Saito; C Kawauchi; H Hinohara; F Kunimoto
Journal:  Br J Anaesth       Date:  2008-01-04       Impact factor: 9.166

9.  Motor and somatosensory evoked potentials are well maintained in patients given dexmedetomidine during spine surgery.

Authors:  Endrit Bala; Daniel I Sessler; Dileep R Nair; Robert McLain; Jarrod E Dalton; Ehab Farag
Journal:  Anesthesiology       Date:  2008-09       Impact factor: 7.892

10.  Alpha adrenergic receptor subtypes in human, monkey and dog cerebral arteries.

Authors:  N Toda
Journal:  J Pharmacol Exp Ther       Date:  1983-09       Impact factor: 4.030
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  9 in total

1.  Dexmedetomidine: New avenues.

Authors:  Anju Grewal
Journal:  J Anaesthesiol Clin Pharmacol       Date:  2011-07

2.  Effects of preoperative intravenous clonidine in patients undergoing cataract surgery: a double-blind, randomized trial.

Authors:  Ana Ellen Queiroz Santiago; Adriana Machado Issy; Rioko Kimiko Sakata
Journal:  J Ophthalmol       Date:  2014-09-02       Impact factor: 1.909

3.  Intravenous lipid emulsion and dexmedetomidine for treatment of feline permethrin intoxication: a report from 4 cases.

Authors:  G Ceccherini; F Perondi; I Lippi; G Grazia; V Marchetti
Journal:  Open Vet J       Date:  2015-08-19

4.  The effect of dexmedetomidine on cerebral perfusion and oxygenation in healthy piglets with normal and lowered blood pressure anaesthetized with propofol-remifentanil total intravenous anaesthesia.

Authors:  Mai Louise Grandsgaard Mikkelsen; Rikard Ambrus; Rune Rasmussen; James Edward Miles; Helle Harding Poulsen; Finn Borgbjerg Moltke; Thomas Eriksen
Journal:  Acta Vet Scand       Date:  2017-05-03       Impact factor: 1.695

5.  Attenuation of Hemodynamic Response to Skull Pin Head Holder Insertion: Intravenous Clonidine versus Intravenous Lignocaine Infusion.

Authors:  Nethra H Nanjundaswamy; Vinay Marulasiddappa
Journal:  Anesth Essays Res       Date:  2017 Jan-Mar

6.  The influence of norepinephrine and phenylephrine on cerebral perfusion and oxygenation during propofol-remifentanil and propofol-remifentanil-dexmedetomidine anaesthesia in piglets.

Authors:  Mai Louise Grandsgaard Mikkelsen; Rikard Ambrus; Rune Rasmussen; James Edward Miles; Helle Harding Poulsen; Finn Borgbjerg Moltke; Thomas Eriksen
Journal:  Acta Vet Scand       Date:  2018-02-08       Impact factor: 1.695

7.  Effect of Low-Dose Dexmedetomidine on the Anesthetic and Recovery Profile of Sevoflurane-Based Anesthesia in Patients Presenting for Supratentorial Neurosurgeries: A Randomized Double-Blind Placebo-Controlled Trial.

Authors:  Unnikrishnan Prathapadas; Ajay Prasad Hrishi; Arulvelan Appavoo; Smita Vimala; Manikandan Sethuraman
Journal:  J Neurosci Rural Pract       Date:  2020-03-17

8.  Cerebrospinal fluid metabolic profiling reveals divergent modulation of pentose phosphate pathway by midazolam, propofol and dexmedetomidine in patients with subarachnoid hemorrhage: a cohort study.

Authors:  Yi-Chen Li; Rong Wang; Ji-Ye A; Run-Bin Sun; Shi-Jie Na; Tao Liu; Xuan-Sheng Ding; Wei-Hong Ge
Journal:  BMC Anesthesiol       Date:  2022-01-27       Impact factor: 2.217

9.  A prospective randomized study comparing recovery following anesthesia with a combination of intravenous dexmedetomidine and desflurane or sevoflurane in spinal surgeries.

Authors:  Yogita Patil; Suyog Bagade; Nilesh Patil; Nalini Jadhav
Journal:  J Anaesthesiol Clin Pharmacol       Date:  2017 Oct-Dec
  9 in total

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