Literature DB >> 10882355

Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease.

G M Rishton1, D M Retz, P A Tempest, J Novotny, S Kahn, J J Treanor, J D Lile, M Citron.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10882355     DOI： 10.1021/jm990622z

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


× No keyword cloud information.
  10 in total

Review 1.  Spotlight on BACE: the secretases as targets for treatment in Alzheimer disease.

Authors:  C Dingwall
Journal:  J Clin Invest       Date:  2001-11       Impact factor: 14.808

2.  A multi-component reaction (MCR) approach to the synthesis of highly diverse polymers with polypeptide-like features.

Authors:  Claude V Robotham; Christopher Baker; Brian Cuevas; Khalil Abboud; Dennis L Wright
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

3.  Localization of the noncovalent binding site between amyloid-beta-peptide and oleuropein using electrospray ionization FT-ICR mass spectrometry.

Authors:  Fotini N Bazoti; Jonas Bergquist; Karin Markides; Anthony Tsarbopoulos
Journal:  J Am Soc Mass Spectrom       Date:  2008-04-08       Impact factor: 3.109

4.  Noncovalent interaction between amyloid-beta-peptide (1-40) and oleuropein studied by electrospray ionization mass spectrometry.

Authors:  Fotini N Bazoti; Jonas Bergquist; Karin E Markides; Anthony Tsarbopoulos
Journal:  J Am Soc Mass Spectrom       Date:  2006-02-28       Impact factor: 3.109

Review 5.  BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis.

Authors:  Neville Marks; Martin J Berg
Journal:  Neurochem Res       Date:  2009-09-17       Impact factor: 3.996

6.  Changes in gamma-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1.

Authors:  Donald B Carter; Edwige Dunn; Adele M Pauley; Denise D McKinley; Timothy J Fleck; Brenda R Ellerbrook; Nancy C Stratman; Xiangdong Zhou; Carol S Himes; Jeffrey S Nye; Alfredo Tomasselli; Riqiang Yan
Journal:  Mol Neurodegener       Date:  2008-05-12       Impact factor: 14.195

7.  Stereoselective cathodic synthesis of 8-substituted (1R,3R,4S)-menthylamines.

Authors:  Carolin Edinger; Jörn Kulisch; Siegfried R Waldvogel
Journal:  Beilstein J Org Chem       Date:  2015-02-27       Impact factor: 2.883

8.  Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action.

Authors:  Mehmet Oguz; Erbay Kalay; Suleyman Akocak; Alessio Nocentini; Nebih Lolak; Mehmet Boga; Mustafa Yilmaz; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

9.  Development of a high-throughput assay for screening of gamma-secretase inhibitor with endogenous human, mouse or Drosophila gamma-secretase.

Authors:  Lie-Feng Wang; Ru Zhang; Xin Xie
Journal:  Molecules       Date:  2009-09-14       Impact factor: 4.411

10.  Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile.

Authors:  Nabih Lolak; Mehmet Boga; Muhammed Tuneg; Gulcin Karakoc; Suleyman Akocak; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.