| Literature DB >> 10873799 |
Abstract
Recent studies on the transcriptional regulation of two linked, imprinted genes, Igf2 and H19, have provided evidence for a novel mechanism of epigenetic control. DNA methylation controls the activity of an insulator element located between the two linked genes by regulating the binding of the zinc-finger protein CTCF.Entities:
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Year: 2000 PMID: 10873799 DOI: 10.1016/s0960-9822(00)00534-0
Source DB: PubMed Journal: Curr Biol ISSN: 0960-9822 Impact factor: 10.834