Y M Na1, M Y Kim, Y K Kim, Y R Ha, D S Yoon. 1. Department of Rehabilitation Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Koyang, Kyunggi-Do, Korea.
Abstract
OBJECTIVE: To evaluate the effect of early exercise therapy on the natural killer cell cytotoxic activity (NKCA) of patients who had undergone curative resection of stomach cancer. DESIGN: Prospective study. PATIENTS: Thirty-five stomach cancer patients who had undergone curative surgery were randomly divided into an exercise group (n = 17) and a control group (n = 18). INTERVENTION: From postoperative day 2, moderated exercise using arm and bicycle ergometers performed twice a day, 5 times a week, for 14 days. The intensity of exercise was 60% of maximal heart rate. Venous blood samples were obtained on postoperative days 1, 7, and 14. MAIN OUTCOME MEASURE: Mean sequential change of NKCA. RESULTS: The mean sequential change of NKCA decreased until postoperative day 7 and then increased. Mean NKCA of day 7 decreased in both groups, compared with that at postoperative day 1. At day 14, the mean NKCA of the exercise group demonstrated a significant increase compared with that of the control group (p < .05). CONCLUSION: This study suggests that early moderate exercise has a beneficial effect on the function of in vitro NK cells in stomach cancer patients after curative surgery.
RCT Entities:
OBJECTIVE: To evaluate the effect of early exercise therapy on the natural killer cell cytotoxic activity (NKCA) of patients who had undergone curative resection of stomach cancer. DESIGN: Prospective study. PATIENTS: Thirty-five stomach cancerpatients who had undergone curative surgery were randomly divided into an exercise group (n = 17) and a control group (n = 18). INTERVENTION: From postoperative day 2, moderated exercise using arm and bicycle ergometers performed twice a day, 5 times a week, for 14 days. The intensity of exercise was 60% of maximal heart rate. Venous blood samples were obtained on postoperative days 1, 7, and 14. MAIN OUTCOME MEASURE: Mean sequential change of NKCA. RESULTS: The mean sequential change of NKCA decreased until postoperative day 7 and then increased. Mean NKCA of day 7 decreased in both groups, compared with that at postoperative day 1. At day 14, the mean NKCA of the exercise group demonstrated a significant increase compared with that of the control group (p < .05). CONCLUSION: This study suggests that early moderate exercise has a beneficial effect on the function of in vitro NK cells in stomach cancerpatients after curative surgery.
Authors: Rebecca M Speck; Kerry S Courneya; Louise C Mâsse; Sue Duval; Kathryn H Schmitz Journal: J Cancer Surviv Date: 2010-01-06 Impact factor: 4.442
Authors: Richard Crevenna; Manuela Schmidinger; Mohammad Keilani; Martin Nuhr; Hakan Nur; Carina Zöch; Christoph Zielinski; Veronika Fialka-Moser; Michael Quittan Journal: Wien Med Wochenschr Date: 2003
Authors: Richard Crevenna; Christoph Zielinski; Mohammad Yahya Keilani; Manuela Schmidinger; Christian Bittner; Martin Nuhr; Hakan Nur; Christine Marosi; Veronika Fialka-Moser; Michael Quittan Journal: Wien Med Wochenschr Date: 2003
Authors: David J Harriss; N Tim Cable; Keith George; Thomas Reilly; Andrew G Renehan; Najib Haboubi Journal: Sports Med Date: 2007 Impact factor: 11.136
Authors: Jennifer L Steel; Kathryn Bress; Lydia Popichak; Jonathan S Evans; Alexandra Savkova; Michelle Biala; Josh Ordos; Brian I Carr Journal: J Gastrointest Cancer Date: 2014-06
Authors: Wiebke Jensen; Freerk T Baumann; Alexander Stein; Wilhelm Bloch; Carsten Bokemeyer; Maike de Wit; Karin Oechsle Journal: Support Care Cancer Date: 2014-02-15 Impact factor: 3.603