Literature DB >> 10853764

Recessive mutations in SUP35 and SUP45 genes coding for translation release factors affect chromosome stability in Saccharomyces cerevisiae.

A S Borchsenius1, A A Tchourikova, S G Inge-Vechtomov.   

Abstract

Chromosome stability in suppressor mutants for SUP35 and SUP45 genes coding for translation release factors was studied. We obtained spontaneous and UV-induced sup35 or sup45 mutants in a haploid strain disomic for chromosome III and tested the stability of an extra copy of this chromosome. The majority of the mutants showed increased chromosome instability. This phenotype was correlated with an increased sensitivity to the microtubule-poisoning drug benomyl which affects chromosome segregation at anaphase. Our data suggest that termination-translation factors eRF3 and eRF1 control chromosome transmission at mitotic anaphase in Saccharomyces cerevisiae.

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Year:  2000        PMID： 10853764     DOI： 10.1007/s002940050529

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  14 in total

1.  Gene overexpression as a tool for identifying new trans-acting factors involved in translation termination in Saccharomyces cerevisiae.

Authors:  Olivier Namy; Isabelle Hatin; Guillaume Stahl; Hongmei Liu; Stephanie Barnay; Laure Bidou; Jean-Pierre Rousset
Journal:  Genetics       Date:  2002-06       Impact factor: 4.562

2.  The impact of manipulations with cytoplasmically inherited factors on nuclear transmission and degradation in yeast heterokaryons.

Authors:  Olga V Nevzglyadova; Alexey V Artyomov; Ekaterina V Mikhailova; Tonu R Soidla
Journal:  Curr Genet       Date:  2004-03-13       Impact factor: 3.886

3.  Cosuppression of eukaryotic release factor 1-1 in Arabidopsis affects cell elongation and radial cell division.

Authors:  Katherine Anne Petsch; Joshua Mylne; José Ramón Botella
Journal:  Plant Physiol       Date:  2005-08-19       Impact factor: 8.340

4.  Functional role of Tia1/Pub1 and Sup35 prion domains: directing protein synthesis machinery to the tubulin cytoskeleton.

Authors:  Xiang Li; Joseph B Rayman; Eric R Kandel; Irina L Derkatch
Journal:  Mol Cell       Date:  2014-06-26       Impact factor: 17.970

5.  The brefeldin A resistance protein Bfr1p is a component of polyribosome-associated mRNP complexes in yeast.

Authors:  B D Lang; H D Black-Brewster; J L Fridovich-Keil
Journal:  Nucleic Acids Res       Date:  2001-06-15       Impact factor: 16.971

6.  Yeast prion protein derivative defective in aggregate shearing and production of new 'seeds'.

Authors:  A S Borchsenius; R D Wegrzyn; G P Newnam; S G Inge-Vechtomov; Y O Chernoff
Journal:  EMBO J       Date:  2001-12-03       Impact factor: 11.598

7.  Differential expression of the eukaryotic release factor 3 (eRF3/GSPT1) according to gastric cancer histological types.

Authors:  J Malta-Vacas; C Aires; P Costa; A R Conde; S Ramos; A P Martins; C Monteiro; M Brito
Journal:  J Clin Pathol       Date:  2005-06       Impact factor: 3.411

8.  Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway.

Authors:  Céline Chauvin; Samia Salhi; Olivier Jean-Jean
Journal:  Mol Cell Biol       Date:  2007-06-11       Impact factor: 4.272

9.  Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast.

Authors:  Gloria H Merritt; Wesley R Naemi; Pierre Mugnier; Helen M Webb; Mick F Tuite; Tobias von der Haar
Journal:  Nucleic Acids Res       Date:  2010-05-05       Impact factor: 16.971

10.  Eukaryotic release factor 1-2 affects Arabidopsis responses to glucose and phytohormones during germination and early seedling development.

Authors:  Xiangjun Zhou; Peter Cooke; Li Li
Journal:  J Exp Bot       Date:  2009-11-25       Impact factor: 6.992
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