Literature DB >> 10851198

Structural genomics of microbes: an objective.

S H Kim1.   

Abstract

A comparison of the genome sequences of more than 20 microorganisms reveals that a large fraction of the genes have unknown functions. Determining the structures of the proteins coded by these genes may provide additional key information in an effort to uncover the molecular functions of such proteins and new protein fold patterns. Using existing technology, it is possible to obtain a complete sequence complement and a near complete structural complement for a small microbial genome. Such information may provide a comprehensive view of a small organism, which, in turn, can serve as a platform for understanding more complex organisms.

Mesh：

Year:  2000        PMID： 10851198     DOI： 10.1016/s0959-440x(00)00100-7

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  10 in total

1.  Fold prediction of helical proteins using torsion angle dynamics and predicted restraints.

Authors:  Chao Zhang; Jingtong Hou; Sung-Hou Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

2.  Automated protein fold determination using a minimal NMR constraint strategy.

Authors:  Deyou Zheng; Yuanpeng J Huang; Hunter N B Moseley; Rong Xiao; James Aramini; G V T Swapna; Gaetano T Montelione
Journal:  Protein Sci       Date:  2003-06       Impact factor: 6.725

3.  Enlarged FAMSBASE: protein 3D structure models of genome sequences for 41 species.

Authors:  Akihiro Yamaguchi; Mitsuo Iwadate; Ei-ichiro Suzuki; Kei Yura; Shigetsugu Kawakita; Hideaki Umeyama; Mitiko Go
Journal:  Nucleic Acids Res       Date:  2003-01-01       Impact factor: 16.971

4.  Role for NMR in structural genomics.

Authors:  Michael A Kennedy; Gaetano T Montelione; Cheryl H Arrowsmith; John L Markley
Journal:  J Struct Funct Genomics       Date:  2002

5.  Computational structural analysis of proteins of Mycobacterium tuberculosis and a resource for identifying off-targets.

Authors:  Sameer Hassan; Abhimita Debnath; Vasantha Mahalingam; Luke Elizabeth Hanna
Journal:  J Mol Model       Date:  2012-04-27       Impact factor: 1.810

6.  Coverage of whole proteome by structural genomics observed through protein homology modeling database.

Authors:  Kei Yura; Akihiro Yamaguchi; Mitiko Go
Journal:  J Struct Funct Genomics       Date:  2006-12-05

7.  Modeling Protein-Ligand Binding by Mining Minima.

Authors:  Wei Chen; Michael K Gilson; Simon P Webb; Michael J Potter
Journal:  J Chem Theory Comput       Date:  2010-10-08       Impact factor: 6.006

8.  Functional annotation and three-dimensional structure of an incorrectly annotated dihydroorotase from cog3964 in the amidohydrolase superfamily.

Authors:  Argentina Ornelas; Magdalena Korczynska; Sugadev Ragumani; Desigan Kumaran; Tamari Narindoshvili; Brian K Shoichet; Subramanyam Swaminathan; Frank M Raushel
Journal:  Biochemistry       Date:  2012-12-20       Impact factor: 3.162

9.  Using an Escherichia coli cell-free extract to screen for soluble expression of recombinant proteins.

Authors:  Didier Busso; Rosalind Kim; Sung-Hou Kim
Journal:  J Struct Funct Genomics       Date:  2004

10.  Targeting the human cancer pathway protein interaction network by structural genomics.

Authors:  Yuanpeng Janet Huang; Dehua Hang; Long Jason Lu; Liang Tong; Mark B Gerstein; Gaetano T Montelione
Journal:  Mol Cell Proteomics       Date:  2008-05-18       Impact factor: 5.911
  10 in total

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