Literature DB >> 10851013

Mycobacterium smegmatis has two pyrazinamidase enzymes, PncA and pzaA.

M Guo1, Z Sun, Y Zhang.   

Abstract

The Mycobacterium smegmatis pncA gene, encoding nicotinamidase/pyrazinamidase, was identified. While it was similar to counterparts from other mycobacteria, the M. smegmatis PncA had little homology to the other M. smegmatis pyrazinamidase/nicotinamidase, encoded by the pzaA gene. Transformation of Mycobacterium bovis strain BCG with M. smegmatis pncA or pzaA conferred susceptibility to pyrazinamide.

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Year:  2000        PMID： 10851013      PMCID： PMC94569          DOI： 10.1128/JB.182.13.3881-3884.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  22 in total

1.  Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.

Authors:  M Mestdagh; P A Fonteyne; L Realini; R Rossau; G Jannes; W Mijs; K A De Smet; F Portaels; E Van den Eeckhout
Journal:  Antimicrob Agents Chemother       Date:  1999-09       Impact factor: 5.191

2.  pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada.

Authors:  S J Cheng; L Thibert; T Sanchez; L Heifets; Y Zhang
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

3.  Alterations in the superoxide dismutase gene of an isoniazid-resistant strain of Mycobacterium tuberculosis.

Authors:  Y Zhang; M J Garcia; R Lathigra; B Allen; C Moreno; J D van Embden; D Young
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

4.  Testing of susceptibility of Mycobacterium tuberculosis to pyrazinamide: comparison of Bactec method with pyrazinamidase assay.

Authors:  M A Miller; L Thibert; F Desjardins; S H Siddiqi; A Dascal
Journal:  J Clin Microbiol       Date:  1995-09       Impact factor: 5.948

5.  Nicotinamide deamidase from Flavobacterium peregrinum.

Authors:  Y Tanigawa; M Shimoyama; I Ueda
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

6.  Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.

Authors:  A Scorpio; Y Zhang
Journal:  Nat Med       Date:  1996-06       Impact factor: 53.440

7.  Transformation of mycobacterial species using hygromycin resistance as selectable marker.

Authors:  T R Garbe; J Barathi; S Barnini; Y Zhang; C Abou-Zeid; D Tang; R Mukherjee; D B Young
Journal:  Microbiology       Date:  1994-01       Impact factor: 2.777

8.  Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations.

Authors:  Y Zhang; T Garbe; D Young
Journal:  Mol Microbiol       Date:  1993-05       Impact factor: 3.501

9.  Use of pyrazinamidase activity on Mycobacterium tuberculosis as a rapid method for determination of pyrazinamide susceptibility.

Authors:  J K McClatchy; A Y Tsang; M S Cernich
Journal:  Antimicrob Agents Chemother       Date:  1981-10       Impact factor: 5.191

10.  Pyrazinamidase activity of Mycobacterium tuberculosis--a test of sensitivity to pyrazinamide.

Authors:  S S Trivedi; S G Desai
Journal:  Tubercle       Date:  1987-09
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  4 in total

1.  Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy.

Authors:  Anthony D Baughn; Jiaoyu Deng; Catherine Vilchèze; Angelica Riestra; John T Welch; William R Jacobs; Oren Zimhony
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

2.  Role of pncA and rpsA gene sequencing in detection of pyrazinamide resistance in Mycobacterium tuberculosis isolates from southern China.

Authors:  Yaoju Tan; Zuqiong Hu; Tianyu Zhang; Xingshan Cai; Haobin Kuang; Yanwen Liu; Junyu Chen; Feng Yang; Ke Zhang; Shouyong Tan; Yanlin Zhao
Journal:  J Clin Microbiol       Date:  2013-10-16       Impact factor: 5.948

3.  Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.

Authors:  Helena I Boshoff; Valerie Mizrahi; Clifton E Barry
Journal:  J Bacteriol       Date:  2002-04       Impact factor: 3.490

4.  Expression of Mycobacterium smegmatis pyrazinamidase in Mycobacterium tuberculosis confers hypersensitivity to pyrazinamide and related amides.

Authors:  H I Boshoff; V Mizrahi
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490
  4 in total

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