Literature DB >> 10471589

Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.

M Mestdagh1, P A Fonteyne, L Realini, R Rossau, G Jannes, W Mijs, K A De Smet, F Portaels, E Van den Eeckhout.   

Abstract

Sixty-two Mycobacterium tuberculosis isolates were tested for pyrazinamidase activity, and their pyrazinamide susceptibility was determined by the radiometric method. Sequencing of pncA genes in the 23 resistant strains revealed mutations in 16 pyrazinamidase-negative strains, 11 of which had not been previously described. Six isolates containing wild-type pncA might possess alternative resistance mechanisms.

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Year:  1999        PMID： 10471589      PMCID： PMC89471     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Evaluating current methods for determination of the susceptibility of mycobacteria to pyrazinamide, conventional, radiometric Bactec and two methods of pyrazinamidase testing.

Authors:  R R Cutler; P Wilson; J Villarroel; F V Clarke
Journal:  Lett Appl Microbiol       Date:  1997-02       Impact factor: 2.858

2.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

Authors:  R K Saiki; D H Gelfand; S Stoffel; S J Scharf; R Higuchi; G T Horn; K B Mullis; H A Erlich
Journal:  Science       Date:  1988-01-29       Impact factor: 47.728

3.  Pyrazinamide susceptibility and amidase activity of tubercle bacilli.

Authors:  K Konno; F M Feldmann; W McDermott
Journal:  Am Rev Respir Dis       Date:  1967-03

4.  Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis.

Authors:  D van Soolingen; P W Hermans; P E de Haas; D R Soll; J D van Embden
Journal:  J Clin Microbiol       Date:  1991-11       Impact factor: 5.948

5.  Simple pyrazinamidase and urease tests for routine identification of mycobacteria.

Authors:  L G Wayne
Journal:  Am Rev Respir Dis       Date:  1974-01

6.  Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis.

Authors:  A Scorpio; P Lindholm-Levy; L Heifets; R Gilman; S Siddiqi; M Cynamon; Y Zhang
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

7.  Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms.

Authors:  S Sreevatsan; X Pan; Y Zhang; B N Kreiswirth; J M Musser
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

8.  Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.

Authors:  A Scorpio; Y Zhang
Journal:  Nat Med       Date:  1996-06       Impact factor: 53.440

9.  Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

Authors:  K Hirano; M Takahashi; Y Kazumi; Y Fukasawa; C Abe
Journal:  Tuber Lung Dis       Date:  1997

10.  Determination of pyrazinamide MICs for Mycobacterium tuberculosis at different pHs by the radiometric method.

Authors:  M Salfinger; L B Heifets
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191
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  33 in total

1.  pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal.

Authors:  Isabel Portugal; Luís Barreiro; José Moniz-Pereira; Laura Brum
Journal:  Antimicrob Agents Chemother       Date:  2004-07       Impact factor: 5.191

2.  Spectrum of pncA mutations in multidrug-resistant Mycobacterium tuberculosis isolates obtained in Latvia.

Authors:  Tatjana Tracevska; Inta Jansone; Viesturs Baumanis; Anda Nodieva; Olgerts Marga; Girts Skenders
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

3.  Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance.

Authors:  Mirko Zimic; Patricia Fuentes; Robert H Gilman; Andrés H Gutiérrez; Daniela Kirwan; Patricia Sheen
Journal:  Tuberculosis (Edinb)       Date:  2011-10-17       Impact factor: 3.131

4.  Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil.

Authors:  Vívian de F Sumnienski Rodrigues; Maria Alice Telles; Marta Osório Ribeiro; Patrícia Izquierdo Cafrune; Maria Lucia Rosa Rossetti; Arnaldo Zaha
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

5.  Potential for erroneous results indicating resistance when using the Bactec MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide.

Authors:  Pamela Chedore; Lina Bertucci; Joyce Wolfe; Meenu Sharma; Frances Jamieson
Journal:  J Clin Microbiol       Date:  2009-11-18       Impact factor: 5.948

6.  pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada.

Authors:  S J Cheng; L Thibert; T Sanchez; L Heifets; Y Zhang
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

7.  Mycobacterium smegmatis has two pyrazinamidase enzymes, PncA and pzaA.

Authors:  M Guo; Z Sun; Y Zhang
Journal:  J Bacteriol       Date:  2000-07       Impact factor: 3.490

8.  Peruvian and globally reported amino acid substitutions on the Mycobacterium tuberculosis pyrazinamidase suggest a conserved pattern of mutations associated to pyrazinamide resistance.

Authors:  Mirko Zimic; Patricia Sheen; Miguel Quiliano; Andrés Gutierrez; Robert H Gilman
Journal:  Infect Genet Evol       Date:  2009-12-04       Impact factor: 3.342

9.  Surveillance of pyrazinamide susceptibility among multidrug-resistant Mycobacterium tuberculosis isolates from Siriraj Hospital, Thailand.

Authors:  Jirarut Jonmalung; Therdsak Prammananan; Manoon Leechawengwongs; Angkana Chaiprasert
Journal:  BMC Microbiol       Date:  2010-08-20       Impact factor: 3.605

10.  Molecular epidemiological study of pyrazinamide-resistance in clinical isolates of mycobacterium tuberculosis from South India.

Authors:  Muthuraj Muthaiah; Sridharan Jagadeesan; Nisha Ayalusamy; Manupriya Sreenivasan; Sambamurthy Sangamesvara Prabhu; Usharani Muthuraj; Kamatchiyammal Senthilkumar; Saroja Veerappan
Journal:  Int J Mol Sci       Date:  2010-07-07       Impact factor: 5.923
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