Literature DB >> 1084409

Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance.

J C Cambier, J R Kettman, E S Vitetta, J W Uhr.   

Abstract

The relative susceptibility of neonatal and adult murine splenocytes to induction of B-cell tolerance was studied in vitro. Adult cells required approximately 1,000-fold more trinitrophenyl-human gamma globulin to be rendered tolerant than did cells from 9- to 12-day-old neonates. The potential effects of suppressor T cells were excluded by pretreating the cultured B cells with anti-Thy-1 and C' and the helper T cells with anti-Ly-2.2 and C'. The possible role of cell surface immunoglobulin isotypes in contributing to this observed difference is discussed.

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Year:  1976        PMID： 1084409      PMCID： PMC2190369          DOI： 10.1084/jem.144.1.293

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  19 in total

1.  Ontogeny of the antibody-forming cell line in mice. I. Kinetics of appearance of mature B cells.

Authors:  Y J Rosenberg; A J Cunningham
Journal:  Eur J Immunol       Date:  1976-07       Impact factor: 5.532

2.  In vitro induction of specific unresponsiveness against the 2,4,6-trinitrophenyl determinant. I. The induction of unresponsiveness.

Authors:  J Kettman
Journal:  J Immunol       Date:  1974-03       Impact factor: 5.422

3.  Differential stimulation of precursor cells and carrier-specific thymus-derived cell activity in the in vivo reponse to heterologous erythrocytes in mice.

Authors:  R Falkoff; J Kettman
Journal:  J Immunol       Date:  1972-01       Impact factor: 5.422

4.  Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells.

Authors:  E S Golub
Journal:  Cell Immunol       Date:  1971-08       Impact factor: 4.868

5.  Neonatal tolerance induced by antibody against antigen-specific receptor.

Authors:  D S Strayer; H Cosenza; W M Lee; D A Rowley; H Köhler
Journal:  Science       Date:  1974-11-15       Impact factor: 47.728

6.  An in vitro primary immune response to 2,4,6-trinitrophenyl substituted erythrocytes: response against carrier and hapten.

Authors:  J Kettman; R W Dutton
Journal:  J Immunol       Date:  1970-06       Impact factor: 5.422

7.  Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self.

Authors:  M C Raff; J J Owen; M D Cooper; A R Lawton; M Megson; W E Gathings
Journal:  J Exp Med       Date:  1975-11-01       Impact factor: 14.307

8.  Ontogeny of B lymphocytes. II. Relative rates of appearance of lymphocytes bearing surface immunoglobulin and complement receptors.

Authors:  M C Gelfand; G J Elfenbein; M M Frank; W E Paul
Journal:  J Exp Med       Date:  1974-05-01       Impact factor: 14.307

9.  The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.

Authors:  N R Klinman; J L Press
Journal:  J Exp Med       Date:  1975-05-01       Impact factor: 14.307

10.  Characterization of splenic lymphoid cells in fetal and newborn mice.

Authors:  P G Spear; A L Wang; U Rutishauser; G M Edelman
Journal:  J Exp Med       Date:  1973-09-01       Impact factor: 14.307
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  29 in total

1.  Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.

Authors:  Bao Hoa Duong; Takayuki Ota; Djemel Aït-Azzouzene; Miyo Aoki-Ota; José Luis Vela; Christoph Huber; Kevin Walsh; Amanda L Gavin; David Nemazee
Journal:  J Immunol       Date:  2010-03-15       Impact factor: 5.422

Review 2.  Immunosenescence and immune response in organ transplantation.

Authors:  Paulo Ney Aguiar Martins; Stefan G Tullius; James F Markmann
Journal:  Int Rev Immunol       Date:  2013-10-15       Impact factor: 5.311

3.  Isoelectric focusing spectra of anti-bacterial alpha-amylase antibody unique for antigen-induced suppression.

Authors:  S Nakashima
Journal:  Immunology       Date:  1986-02       Impact factor: 7.397

4.  Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD.

Authors:  J C Cambier; F S Ligler; J W Uhr; J R Kettman; E S Vitetta
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

5.  Control of proliferation and differentiation in B lymphocytes by anti-Ig antibodies and a serum-derived cofactor.

Authors:  C L Sidman; E R Unanue
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

6.  Ontogeny of murine-B-lymphocytes. Avidity of antigen binding cells in neonatal and adult mice.

Authors:  S Marshall-Clarke; J H Playfair
Journal:  Immunology       Date:  1978-06       Impact factor: 7.397

7.  The use of immunological tolerance to investigate B lymphocyte replacement kinetics in chickens.

Authors:  P Klein; T Hraba; J Dolezal
Journal:  J Math Biol       Date:  1983       Impact factor: 2.259

8.  Generation of immunological memory in tolerant mice.

Authors:  J P Tite; J H Playfair
Journal:  Immunology       Date:  1978-06       Impact factor: 7.397

9.  Ontogeny of B-lymphocyte function. IX. Difference in the time of maturation of the capacity of B lymphocytes from foetal and neonatal mice to produce a heterogeneous antibody response to thymic-dependent and thymic-independent antigens.

Authors:  D H Sherr; M R Szewczuk; A Cusano; W Rappaport; G W Siskind
Journal:  Immunology       Date:  1979-04       Impact factor: 7.397

10.  Establishing anergy as a bona fide in vivo mechanism of B cell tolerance.

Authors:  Andrew Getahun; Shannon K O'Neill; John C Cambier
Journal:  J Immunol       Date:  2009-11-01       Impact factor: 5.422
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