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Literature DB >> 308037

Ontogeny of murine-B-lymphocytes. Avidity of antigen binding cells in neonatal and adult mice.

Abstract

The heterogeneity of avidity of DNP-binding (rosetting) cells has been studied in mice of various ages, in an attempt to learn more about the development of antibody diversity. The results indicate that during the neonatal period murine B cells show a limited heterogeneity of avidity with no "high" avidity ABC being detectable. This implies that the full repertoire of anti-DNP antibodies is only gradually acquired during ontogeny. The results are interpreted as favouring the hypothesis that somatic events are important in the generation of antibody diversity.

Entities: Chemical Species

Mesh：

Substances：
Antigens

Year: 1978 PMID： 308037 PMCID： PMC1457415

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

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References

18 in total

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Authors: J M Decker; J Clarke; L M Bradley; A Miller; E E Sercarz
Journal: J Immunol Date: 1974-12 Impact factor: 5.422

6. Ontogeny of B-lymphocyte function. I. Restricted heterogeneity of the antibody response of B lymphocytes from neonatal and fetal mice.

Authors: E A Goidl; G W Siskind
Journal: J Exp Med Date: 1974-11-01 Impact factor: 14.307

7. Ontogeny of B-lymphocyte function. III. In vivo and in vitro studies on the ease of tolerance induction in B lymphocytes from fetal, neonatal, and adult mice.

Authors: M R Szewczuk; G W Siskind
Journal: J Exp Med Date: 1977-06-01 Impact factor: 14.307

8. The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.

Authors: N R Klinman; J L Press
Journal: J Exp Med Date: 1975-05-01 Impact factor: 14.307

9. In vitro tolerance induction of neonatal murine B cells.

Authors: E S Metcalf; N R Klinman
Journal: J Exp Med Date: 1976-06-01 Impact factor: 14.307

10. Characterization of splenic lymphoid cells in fetal and newborn mice.

Authors: P G Spear; A L Wang; U Rutishauser; G M Edelman
Journal: J Exp Med Date: 1973-09-01 Impact factor: 14.307

Ontogeny of murine-B-lymphocytes. Avidity of antigen binding cells in neonatal and adult mice.

1. Presence of antigen-binding cells for five diverse antigens at the onset of lymphoid development: lack of evidence for somatic diversification during ontogeny.

2. Selection under a somatic model.

Review 3. Somatic translocation of antibody genes.

4. Hemolytic plaque inhibition: the physical chemical limits on its use as an affinity assay.

Review 5. The generation of antibody diversity: its dependence on antigenic stimulation.

6. Ontogeny of B-lymphocyte function. I. Restricted heterogeneity of the antibody response of B lymphocytes from neonatal and fetal mice.

7. Ontogeny of B-lymphocyte function. III. In vivo and in vitro studies on the ease of tolerance induction in B lymphocytes from fetal, neonatal, and adult mice.

8. The characterization fo the B-cell repertoire specific for the 2,4-dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice.

9. In vitro tolerance induction of neonatal murine B cells.

10. Characterization of splenic lymphoid cells in fetal and newborn mice.