Literature DB >> 24127845

Immunosenescence and immune response in organ transplantation.

Paulo Ney Aguiar Martins1, Stefan G Tullius, James F Markmann.   

Abstract

The immune system undergoes a complex and continuous remodeling with aging. Immunosenescence results into both quantitative and qualitative changes of specific cellular subpopulations that have major impact on allorecognition and alloresponse, and consequently on graft rejection and tolerance. Here, we are going to review the immunological changes associated with the aging process relevant for transplantation. Interventions to selectively target changes associated with the senescence process seem promising therapeutic strategies to improve transplantation outcome.

Entities:  

Keywords:  aging; elderly; immunosenescence; transplantation

Mesh：

Year:  2013        PMID： 24127845      PMCID： PMC5497513          DOI： 10.3109/08830185.2013.829469

Source DB:  PubMed          Journal:  Int Rev Immunol        ISSN： 0883-0185            Impact factor:   5.311


  137 in total

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Review 4.  The innate immune system in allograft rejection and tolerance.

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Journal:  J Immunol       Date:  2007-06-15       Impact factor: 5.422

Review 5.  Rethinking chronic allograft nephropathy: the concept of accelerated senescence.

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Journal:  J Am Soc Nephrol       Date:  1999-01       Impact factor: 10.121

6.  Neonatal transplantation tolerance is associated with a systemic reduction in memory cells, altered chimeric cell phenotype, and modified eicosanoid and cytokine production.

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Journal:  Transplantation       Date:  1996-04-27       Impact factor: 4.939

7.  The combination of donor and recipient age is critical in determining host immunoresponsiveness and renal transplant outcome.

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Journal:  Ann Surg       Date:  2010-10       Impact factor: 12.969

8.  The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure.

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9.  Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity.

Authors:  Laura Tsaknaridis; Leslie Spencer; Nicole Culbertson; Kevin Hicks; Dorian LaTocha; Yuan K Chou; Ruth H Whitham; Antony Bakke; Richard E Jones; Halina Offner; Dennis N Bourdette; Arthur A Vandenbark
Journal:  J Neurosci Res       Date:  2003-10-15       Impact factor: 4.164

10.  Changes in lymphocyte subsets and immune competence in very advanced age.

Authors:  L Lehtonen; J Eskola; O Vainio; A Lehtonen
Journal:  J Gerontol       Date:  1990-05
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  16 in total

Review 1.  Changes of T-cell Immunity Over a Lifetime.

Authors:  Yeqi Nian; Koichiro Minami; Ryoichi Maenesono; Jasper Iske; Jinrui Yang; Haruhito Azuma; Abdala ElKhal; Stefan G Tullius
Journal:  Transplantation       Date:  2019-11       Impact factor: 4.939

2.  Differences in Phenotypes and Liver Transplantation Outcomes by Age Group in Patients with Primary Sclerosing Cholangitis.

Authors:  Jacqueline B Henson; Yuval A Patel; Julius M Wilder; Jiayin Zheng; Shein-Chung Chow; Lindsay Y King; Andrew J Muir
Journal:  Dig Dis Sci       Date:  2017-04-08       Impact factor: 3.199

3.  The Risk of Postkidney Transplant Outcomes by Induction Choice Differs by Recipient Age.

Authors:  JiYoon B Ahn; Sunjae Bae; Nadia M Chu; Lingyu Wang; Jongyeon Kim; Mark Schnitzler; Gregory P Hess; Krista L Lentine; Dorry L Segev; Mara A McAdams-DeMarco
Journal:  Transplant Direct       Date:  2021-06-18

4.  Codominant Role of Interferon-γ- and Interleukin-17-Producing T Cells During Rejection in Full Facial Transplant Recipients.

Authors:  T J Borges; J T O'Malley; L Wo; N Murakami; B Smith; J Azzi; S Tripathi; J D Lane; E M Bueno; R A Clark; S G Tullius; A Chandraker; C G Lian; G F Murphy; T B Strom; B Pomahac; N Najafian; L V Riella
Journal:  Am J Transplant       Date:  2016-04-07       Impact factor: 8.086

5.  Association of Cold Ischemia Time With Acute Renal Transplant Rejection.

Authors:  Merve Postalcioglu; Arnaud D Kaze; Benjamin C Byun; Andrew Siedlecki; Stefan G Tullius; Edgar L Milford; Julie M Paik; Reza Abdi
Journal:  Transplantation       Date:  2018-07       Impact factor: 4.939

6.  Pre-transplant donor-specific T-cell alloreactivity is strongly associated with early acute cellular rejection in kidney transplant recipients not receiving T-cell depleting induction therapy.

Authors:  Elena Crespo; Marc Lucia; Josep M Cruzado; Sergio Luque; Edoardo Melilli; Anna Manonelles; Nuria Lloberas; Joan Torras; Josep M Grinyó; Oriol Bestard
Journal:  PLoS One       Date:  2015-02-17       Impact factor: 3.240

7.  Differences in Gene Expression in Older Compared With Younger Kidney Transplant Recipients.

Authors:  Joanna M Schaenman; Maura Rossetti; Erik Lum; Basmah Abdalla; Suphamai Bunnapradist; Thu-Phuong Pham; Gabriel Danovitch; Elaine F Reed; Steve Cole
Journal:  Transplant Direct       Date:  2019-03-04

8.  Immunosuppression Considerations for Older Kidney Transplant Recipients.

Authors:  Wisit Cheungpasitporn; Krista L Lentine; Jane C Tan; Matthew Kaufmann; Yasar Caliskan; Suphamai Bunnapradist; Ngan N Lam; Mark Schnitzler; David A Axelrod
Journal:  Curr Transplant Rep       Date:  2021-04-06

9.  CTLA4-Ig prolongs graft survival specifically in young but not old mice.

Authors:  Timm Heinbokel; Markus Quante; Jasper Iske; Yeqi Nian; Ryoichi Maenosono; Koichiro Minami; Yang Liu; Haruhito Azuma; Abdallah Elkhal; Stefan G Tullius
Journal:  Am J Transplant       Date:  2020-09-03       Impact factor: 8.086

10.  The Autoimmune-Associated Single Nucleotide Polymorphism Within PTPN22 Correlates With Clinical Outcome After Lung Transplantation.

Authors:  Kevin Budding; Jessica van Setten; Eduard A van de Graaf; Oliver A van Rossum; Tineke Kardol-Hoefnagel; Johanna M Kwakkel-van Erp; Erik-Jan D Oudijk; C Erik Hack; Henderikus G Otten
Journal:  Front Immunol       Date:  2019-01-17       Impact factor: 7.561
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