Literature DB >> 10841575

Intergeneric poliovirus recombinants for the treatment of malignant glioma.

M Gromeier1, S Lachmann, M R Rosenfeld, P H Gutin, E Wimmer.   

Abstract

Poliovirus neuropathogenicity depends on sequences within the 5' nontranslated region of the virus. Exchange of the poliovirus internal ribosomal entry site with its counterpart from human rhinovirus type 2 resulted in attenuation of neurovirulence in primates. Despite deficient virus propagation in cells of neuronal origin, nonpathogenic polio recombinants retain excellent growth characteristics in cell lines derived from glial neoplasms. Susceptibility of malignant glioma cells to poliovirus may be mediated by expression of a poliovirus receptor, CD155, in glial neoplasms. Intergeneric polio recombinants with heterologous internal ribosomal entry site elements unfolded strong oncolytic potential against experimentally induced gliomas in athymic mice. Our observations suggest that highly attenuated poliovirus recombinants may have applicability as biotherapeutic antineoplastic agents.

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Year:  2000        PMID： 10841575      PMCID： PMC18745          DOI： 10.1073/pnas.97.12.6803

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Expression of the neural cell adhesion molecule in astrocytic tumors: an inverse correlation with malignancy.

Authors:  H Sasaki; K Yoshida; E Ikeda; H Asou; M Inaba; M Otani; T Kawase
Journal:  Cancer       Date:  1998-05-15       Impact factor: 6.860

2.  Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily.

Authors:  C L Mendelsohn; E Wimmer; V R Racaniello
Journal:  Cell       Date:  1989-03-10       Impact factor: 41.582

3.  A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation.

Authors:  S K Jang; H G Kräusslich; M J Nicklin; G M Duke; A C Palmenberg; E Wimmer
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103

4.  Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis.

Authors:  R B Ren; F Costantini; E J Gorgacz; J J Lee; V R Racaniello
Journal:  Cell       Date:  1990-10-19       Impact factor: 41.582

5.  Monoclonal antibody identification of a 100-kDa membrane protein in HeLa cells and human spinal cord involved in poliovirus attachment.

Authors:  M P Shepley; B Sherry; H L Weiner
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

Review 6.  Characterization, cloning and expression of the Tage4 gene, a member of the immunoglobulin superfamily.

Authors:  M G Denis
Journal:  Int J Oncol       Date:  1998-05       Impact factor: 5.650

7.  The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule.

Authors:  M Lopez; M Aoubala; F Jordier; D Isnardon; S Gomez; P Dubreuil
Journal:  Blood       Date:  1998-12-15       Impact factor: 22.113

8.  Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA.

Authors:  J Pelletier; N Sonenberg
Journal:  Nature       Date:  1988-07-28       Impact factor: 49.962

9.  Reovirus therapy of tumors with activated Ras pathway.

Authors:  M C Coffey; J E Strong; P A Forsyth; P W Lee
Journal:  Science       Date:  1998-11-13       Impact factor: 47.728

10.  Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence.

Authors:  M Gromeier; B Bossert; M Arita; A Nomoto; E Wimmer
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103
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  117 in total

1.  Glioblastoma multiforme: the terminator.

Authors:  E C Holland
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

Review 2.  Immunotherapy for primary brain tumors: no longer a matter of privilege.

Authors:  Peter E Fecci; Amy B Heimberger; John H Sampson
Journal:  Clin Cancer Res       Date:  2014-11-15       Impact factor: 12.531

3.  Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region.

Authors:  Elena Dobrikova; Paola Florez; Shelton Bradrick; Matthias Gromeier
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-26       Impact factor: 11.205

Review 4.  Oncolytic virus therapy for glioblastoma multiforme: concepts and candidates.

Authors:  Guido Wollmann; Koray Ozduman; Anthony N van den Pol
Journal:  Cancer J       Date:  2012 Jan-Feb       Impact factor: 3.360

5.  MAPK signal-integrating kinase controls cap-independent translation and cell type-specific cytotoxicity of an oncolytic poliovirus.

Authors:  Christian Goetz; Richard G Everson; Linda C Zhang; Matthias Gromeier
Journal:  Mol Ther       Date:  2010-07-20       Impact factor: 11.454

6.  Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites.

Authors:  Andrew T Dufresne; Elena Y Dobrikova; Stacie Schmidt; Matthias Gromeier
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

7.  Function of neuronal nitric oxide synthase enzyme in temozolomide-induced damage of astrocytic tumor cells.

Authors:  Fernando Francisco Borges Resende; Simoneide Souza Titze-de-Almeida; Ricardo Titze-de-Almeida
Journal:  Oncol Lett       Date:  2018-02-01       Impact factor: 2.967

Review 8.  Targeting PVR (CD155) and its receptors in anti-tumor therapy.

Authors:  Paola Kučan Brlić; Tihana Lenac Roviš; Guy Cinamon; Pini Tsukerman; Ofer Mandelboim; Stipan Jonjić
Journal:  Cell Mol Immunol       Date:  2018-10-01       Impact factor: 11.530

9.  Advances in the mechanisms of action of cancer-targeting oncolytic viruses.

Authors:  Cun-Zhi Lin; Gui-Ling Xiang; Xin-Hong Zhu; Lu-Lu Xiu; Jia-Xing Sun; Xiao-Yuan Zhang
Journal:  Oncol Lett       Date:  2018-01-19       Impact factor: 2.967

10.  Evaluation of IRES-mediated, cell-type-specific cytotoxicity of poliovirus using a colorimetric cell proliferation assay.

Authors:  Xiaoyi Yang; Eying Chen; Hengguang Jiang; Karen Muszynski; Raymond D Harris; Steven L Giardina; Matthias Gromeier; Gautam Mitra; Gopalan Soman
Journal:  J Virol Methods       Date:  2008-11-08       Impact factor: 2.014
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