Literature DB >> 1084153

Effect of aprotinin on immunological resistance in tumour-bearing animals.

A L Latner, G A Turner.   

Abstract

Previous studies suggested that aprotinin might enhance the host's immunological resistance to tumours. This possibility has now been further investigated by studying the behaviour of tumours in both hamsters and mice. A second tumour graft in tumour-bearing hamsters appeared more rapidly than the first. Prior administration of aprotinin abolished this effect. Pretreatment of non-cancerous mice with cortisone nullified the effectiveness of aprotinin in inhibiting the growth of a subsequent tumour graft. These results are interpreted as additional evidence that aprotinin enhances the immunological system against tumour cells.

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Year:  1976        PMID： 1084153      PMCID： PMC2024953          DOI： 10.1038/bjc.1976.84

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  6 in total

1.  Cortisol inhibition of immunologic activity in guinea pig alveolar cells.

Authors:  H R Gaumer; J E Salvaggio; W L Weston; H N Claman
Journal:  Int Arch Allergy Appl Immunol       Date:  1974

2.  Aprotinin, a carbohydrate-binding protein.

Authors:  R W Stoddart; J A Kernan
Journal:  Histochemie       Date:  1973-03-26

3.  Effect of L-asparaginase and hydrocortisone on human lymphocyte transformation and production of a mononuclear leucocyte chemotactic factor in vitro.

Authors:  H Rühl; W Vogt; G Bochert; S Schmidt; R Moelle; H Schaoua
Journal:  Immunology       Date:  1974-05       Impact factor: 7.397

4.  Lymphocyte in vitro cytotoxicity: correlation of derepression with release of lymphotoxin from human lymphocytes.

Authors:  T W Williams; G A Granger
Journal:  J Immunol       Date:  1969-08       Impact factor: 5.422

5.  Glucocorticoid suppression of macrophage migration inhibitory factor.

Authors:  J E Balow; A S Rosenthal
Journal:  J Exp Med       Date:  1973-04-01       Impact factor: 14.307

6.  Anti-tumour activity of aprotinin.

Authors:  A L Latner; E Longstaff; G A Turner
Journal:  Br J Cancer       Date:  1974-07       Impact factor: 7.640
  6 in total
  7 in total

1.  The influence of the protease inhibitor aprotinin on tumor invasion of three cell lines in vitro.

Authors:  E Prange; W Schroyens; H Pralle
Journal:  Clin Exp Metastasis       Date:  1988 Mar-Apr       Impact factor: 5.150

2.  Enhancement of mechanisms acting against mammary carcinoma: pancreatic trypsin inhibitor.

Authors:  A A Hakim
Journal:  Klin Wochenschr       Date:  1978-08-01

3.  Post operative stimulation of cell mediated immunity.

Authors:  J A Smith; W S Hendry; J L Duncan; J N Norman
Journal:  Klin Wochenschr       Date:  1985-10-01

Review 4.  Cell detachment and metastasis.

Authors:  L Weiss; P M Ward
Journal:  Cancer Metastasis Rev       Date:  1983       Impact factor: 9.264

5.  Aprotinin and growth of Walker 256 carcinosarcoma in the rat.

Authors:  A W Thomson; R G Pugh-Humphreys; C H Horne; D J Tweedle
Journal:  Br J Cancer       Date:  1977-04       Impact factor: 7.640

6.  TEEM-test studies on effect of aprotinin on in vitro response of cancer patients' lymphocytes to PPD.

Authors:  J G Freeman; A L Latner; B K Shenton; G A Turner; C W Venables
Journal:  Br J Cancer       Date:  1978-11       Impact factor: 7.640

7.  Endocytosis of the antiprotease aprotinin by Landschütz ascites carcinoma cells and its effects in vitro and in vivo.

Authors:  A W Thomson; D J Tweedie; R G Pugh-Humphreys; M Arthur
Journal:  Br J Cancer       Date:  1978-07       Impact factor: 7.640
  7 in total

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