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Literature DB >> 4547138

Anti-tumour activity of aprotinin.

Abstract

A malignant invasive fibrosarcoma in hamsters and a malignant mammary carcinoma in mice were each challenged with the broad spectrum proteinase inhibitor aprotinin (Trasylol). In both tumour systems, significant anti-tumour effects of aprotinin were observed. Variations in the site and dosage of aprotinin application were made in an attempt to improve the chemotherapeutic response.

Entities: Disease Species

Mesh：

Substances：
Aprotinin

Year: 1974 PMID： 4547138 PMCID： PMC2009194 DOI： 10.1038/bjc.1974.113

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

13 in total

1. Increase of lysosomal enzymes in skin cancers.

Authors: R J Shamberger; G Rudolph
Journal: Nature Date: 1967-02-11 Impact factor: 49.962

2. Effect of collagenolytic activity in basal cell epithelioma of the skin on reconstituted collagen and physical properties and kinetics of the crude enzyme.

Authors: Y Yamanishi; M K Dabbous; K Hashimoto
Journal: Cancer Res Date: 1972-11 Impact factor: 12.701

3. Collagenolytic activity of sarcoma tissues in culture.

Authors: A C Taylor; B M Levy; J W Simpson
Journal: Nature Date: 1970-10-24 Impact factor: 49.962

4. Inhibition of tumorigenesis in mouse skin by leupeptin, a protease inhibitor from Actinomycetes.

Authors: M Hozumi; M Ogawa; T Sugimura; T Takeuchi; H Umezawa
Journal: Cancer Res Date: 1972-08 Impact factor: 12.701

5. Proteolytic enzymes initiating cell division and escape from contact inhibition of growth.

Authors: M M Burger
Journal: Nature Date: 1970-07-11 Impact factor: 49.962

6. Tumorigenesis in mouse skin: inhibition by synthetic inhibitors of proteases.

Authors: W Troll; A Klassen; A Janoff
Journal: Science Date: 1970-09-18 Impact factor: 47.728

7. Release from density dependent growth inhibition by proteolytic enzymes.

Authors: B M Sefton; H Rubin
Journal: Nature Date: 1970-08-22 Impact factor: 49.962

8. Collagenolytic enzymes in human neoplasms.

Authors: M H Dresden; S A Heilman; J D Schmidt
Journal: Cancer Res Date: 1972-05 Impact factor: 12.701

9. Effects of protease inhibitors on growth of hamster tumor cells in culture.

Authors: I E Goetz; C Weinstein; E Roberts
Journal: Cancer Res Date: 1972-11 Impact factor: 12.701

10. Enhanced malignant behaviour of cells treated with crude rat liver histone.

Authors: A L Latner; E Longstaff; G A Turner
Journal: Br J Cancer Date: 1973-03 Impact factor: 7.640

16 in total

1. The influence of the protease inhibitor aprotinin on tumor invasion of three cell lines in vitro.

Authors: E Prange; W Schroyens; H Pralle
Journal: Clin Exp Metastasis Date: 1988 Mar-Apr Impact factor: 5.150

2. The in vitro effect of aprotinin upon spleen cells from normal and tumour-bearing mice exposed to PPD and tumour cells.

Authors: J G Freeman; A L Latner; G A Turner; C W Venables
Journal: Experientia Date: 1980-02-15

Review 9. Cell detachment and metastasis.

Authors: L Weiss; P M Ward
Journal: Cancer Metastasis Rev Date: 1983 Impact factor: 9.264

10. Present status and upcoming prospects of hedgehog pathway inhibitors in small cell lung cancer therapy.

Authors: Syed Hassan Abbas Naqvi; Syed Hassan Shiraz Naqvi; Muhammad Yasin Bandukda; Syed Mumtaz Ali Naqvi
Journal: Infect Agent Cancer Date: 2013-05-22 Impact factor: 2.965