OBJECTIVE: To determine the subcutaneous absorption rates and the appearance in plasma of 3 formulations of the long-acting human insulin analog insulin glargine (HOE 901) differing only in zinc content (15, 30, and 80 microg/ml). RESEARCH DESIGN AND METHODS: We conducted 2 studies. Study 1 compared the subcutaneous abdominal injection of 0.15 U/kg of 125I-labeled insulin glargine[15], insulin glargine[80], NPH insulin, and placebo. In study 2, 0.2 U/kg of insulin glargine[30] was injected into the arm, leg, and abdominal regions. Both studies had a randomized crossover design; each enrolled 12 healthy men, aged 18-50 years. RESULTS: In study 1, the time in hours for 25% of the administered radioactivity to disappear after bolus subcutaneous injection (T75%) for NPH insulin indicated a significantly faster absorption rate compared with the 2 insulin glargine formulations (3.2 vs. 8.8 and 11.0 h, respectively P < 0.0001). Mean residual radioactivity with NPH insulin was also significantly lower at 24 h (21.9 vs. 43.8 and 52.2%, P < 0.0001). The calculated plasma exogenous insulin concentrations after NPH insulin were substantially higher than those with insulin glargine, reaching a peak within the first 6 h after administration before declining. Insulin glargine, however, did not exhibit a distinct peak. Weighted average plasma glucose concentration between 0 and 6 h was significantly lower after NPH compared with insulin glargine (P < 0.001). In study 2, there were no significant differences in the absorption characteristics of insulin glargine between the 3 injection sites (T75% = 11.9, 15.3, and 13.2 h for arm, leg, and abdomen, respectively) or in residual radioactivity at 24 h. CONCLUSIONS: Subcutaneous absorption of insulin glargine is delayed compared with NPH insulin. There is little or no difference in the absorption rate of insulin glargine between the main subcutaneous injection sites.
RCT Entities:
OBJECTIVE: To determine the subcutaneous absorption rates and the appearance in plasma of 3 formulations of the long-acting humaninsulin analog insulinglargine (HOE 901) differing only in zinc content (15, 30, and 80 microg/ml). RESEARCH DESIGN AND METHODS: We conducted 2 studies. Study 1 compared the subcutaneous abdominal injection of 0.15 U/kg of 125I-labeled insulinglargine[15], insulinglargine[80], NPH insulin, and placebo. In study 2, 0.2 U/kg of insulinglargine[30] was injected into the arm, leg, and abdominal regions. Both studies had a randomized crossover design; each enrolled 12 healthy men, aged 18-50 years. RESULTS: In study 1, the time in hours for 25% of the administered radioactivity to disappear after bolus subcutaneous injection (T75%) for NPH insulin indicated a significantly faster absorption rate compared with the 2 insulinglargine formulations (3.2 vs. 8.8 and 11.0 h, respectively P < 0.0001). Mean residual radioactivity with NPH insulin was also significantly lower at 24 h (21.9 vs. 43.8 and 52.2%, P < 0.0001). The calculated plasma exogenous insulin concentrations after NPH insulin were substantially higher than those with insulinglargine, reaching a peak within the first 6 h after administration before declining. Insulinglargine, however, did not exhibit a distinct peak. Weighted average plasma glucose concentration between 0 and 6 h was significantly lower after NPH compared with insulinglargine (P < 0.001). In study 2, there were no significant differences in the absorption characteristics of insulinglargine between the 3 injection sites (T75% = 11.9, 15.3, and 13.2 h for arm, leg, and abdomen, respectively) or in residual radioactivity at 24 h. CONCLUSIONS: Subcutaneous absorption of insulinglargine is delayed compared with NPH insulin. There is little or no difference in the absorption rate of insulinglargine between the main subcutaneous injection sites.
Authors: Tina Parkner; Torben Laursen; Jian-Wen Chen; Marianne K Møller; Henrik F Thomsen; Christina Jørgensen; Jørgen S Smedegaard; Torsten Lauritzen; Jens S Christiansen Journal: J Diabetes Sci Technol Date: 2007-09
Authors: Jason Wong; J Geoffrey Chase; Christopher E Hann; Geoffrey M Shaw; Thomas F Lotz; Jessica Lin; Aaron J Le Compte Journal: J Diabetes Sci Technol Date: 2008-07
Authors: Denisa Janickova Zdarska; Milan Kvapil; Zdenek Rusavy; Michal Krcma; Jan Broz; Bohumila Krivska; Pavla Kadlecova Journal: Wien Klin Wochenschr Date: 2014-02-22 Impact factor: 1.704
Authors: Jason Wong; J Geoffrey Chase; Christopher E Hann; Geoffrey M Shaw; Thomas F Lotz; Jessica Lin; Aaron J Le Compte Journal: J Diabetes Sci Technol Date: 2008-07