Literature DB >> 10818663

Conducting randomized trials in general practice: methodological and practical issues.

E Ward1, M King, M Lloyd, P Bower, K Friedli.   

Abstract

The evaluation of the outcome of health services technologies is a requirement for their efficient provision in clinical practice. The most reliable evidence for treatment efficacy comes from randomized trials. Randomized trials in general practice pose particular methodological and practical difficulties. In this paper, we discuss how best to plan and manage a clinical trial in this setting. We base our discussion on our experience of conducting randomized trials to evaluate the effectiveness of brief psychotherapy in general practice.

Mesh：

Year:  1999        PMID： 10818663      PMCID： PMC1313568     

Source DB:  PubMed          Journal:  Br J Gen Pract        ISSN： 0960-1643            Impact factor:   5.386


  16 in total

1.  Randomised clinical trials with clinician-preferred treatment.

Authors:  E L Korn; S Baumrind
Journal:  Lancet       Date:  1991-01-19       Impact factor: 79.321

2.  Randomised clinical trials in general practice: lessons from a failure.

Authors:  G Tognoni; C Alli; F Avanzini; G Bettelli; F Colombo; R Corso; R Marchioli; A Zussino
Journal:  BMJ       Date:  1991-10-19

3.  Clinical trials in primary care: targeted payments for trials might help improve recruitment and quality.

Authors:  R Foy; J Parry; B McAvoy
Journal:  BMJ       Date:  1998-10-31

Review 4.  Understanding controlled trials. What is a patient preference trial?

Authors:  D J Torgerson; B Sibbald
Journal:  BMJ       Date:  1998-01-31

5.  Patient preferences and randomised clinical trials.

Authors:  C R Brewin; C Bradley
Journal:  BMJ       Date:  1989-07-29

6.  Problems with recruitment in a randomized controlled trial of counselling in general practice: causes and implications.

Authors:  K Fairhurst; C Dowrick
Journal:  J Health Serv Res Policy       Date:  1996-04

7.  Patients' willingness to enter clinical trials: measuring the association with perceived benefit and preference for decision participation.

Authors:  H A Llewellyn-Thomas; M J McGreal; E C Thiel; S Fine; C Erlichman
Journal:  Soc Sci Med       Date:  1991       Impact factor: 4.634

8.  A. I. F. Scott & C. P. L. Freeman's "Edinburgh Primary Care Depression Study.

Authors:  J Scott; C A Moon; C V Blacker; J M Thomas
Journal:  Br J Psychiatry       Date:  1994-03       Impact factor: 9.319

9.  Controlled trials in the evaluation of counselling in general practice.

Authors:  M King; G Broster; M Lloyd; J Horder
Journal:  Br J Gen Pract       Date:  1994-05       Impact factor: 5.386

10.  Participation in a clinical trial: the patients' point of view.

Authors:  M E Mattson; J D Curb; R McArdle
Journal:  Control Clin Trials       Date:  1985-06
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  16 in total

Review 1.  Randomised controlled trials in primary care: case study.

Authors:  S Wilson; B C Delaney; A Roalfe; L Roberts; V Redman; A M Wearn; F D Hobbs
Journal:  BMJ       Date:  2000-07-01

2.  Investigator barriers and preferences to conduct clinical drug trials in Finland: a qualitative study.

Authors:  Tuija Keinonen; Tapani Keränen; Timo Klaukka; Veijof Saano; Pauli Ylitalo; Hannes Enlund
Journal:  Pharm World Sci       Date:  2003-12

3.  An evaluation of the effectiveness of recruitment methods: the staying well after depression randomized controlled trial.

Authors:  Adele Krusche; Isabelle Rudolf von Rohr; Kate Muse; Danielle Duggan; Catherine Crane; J Mark G Williams
Journal:  Clin Trials       Date:  2014-04       Impact factor: 2.486

4.  Results from a trial of an unsupported internet intervention for depressive symptoms.

Authors:  Yan Leykin; Ricardo F Muñoz; Omar Contreras; Melissa D Latham
Journal:  Internet Interv       Date:  2014-10-01

5.  A clinical trial alert tool to recruit large patient samples and assess selection bias in general practice research.

Authors:  Stephanie Heinemann; Sabine Thüring; Sven Wedeken; Tobias Schäfer; Christa Scheidt-Nave; Mirko Ketterer; Wolfgang Himmel
Journal:  BMC Med Res Methodol       Date:  2011-02-15       Impact factor: 4.615

6.  The SCIDOTS Project: evidence of benefits of an integrated tobacco cessation intervention in tuberculosis care on treatment outcomes.

Authors:  Ahmed Awaisu; Mohamad Haniki Nik Mohamed; Noorliza Mohamad Noordin; Noorizan Abd Aziz; Syed Azhar Syed Sulaiman; Abdul Razak Muttalif; Aziah Ahmad Mahayiddin
Journal:  Subst Abuse Treat Prev Policy       Date:  2011-09-23

7.  Buprenorphine versus dihydrocodeine for opiate detoxification in primary care: a randomised controlled trial.

Authors:  Nat M J Wright; Laura Sheard; Charlotte N E Tompkins; Clive E Adams; Victoria L Allgar; Nicola S Oldham
Journal:  BMC Fam Pract       Date:  2007-01-08       Impact factor: 2.497

8.  Identifying strategies to maximise recruitment and retention of practices and patients in a multicentre randomised controlled trial of an intervention to optimise secondary prevention for coronary heart disease in primary care.

Authors:  Claire S Leathem; Margaret E Cupples; Mary C Byrne; Mary O'Malley; Ailish Houlihan; Andrew W Murphy; Susan M Smith
Journal:  BMC Med Res Methodol       Date:  2009-06-19       Impact factor: 4.615

9.  GP Participation and Recruitment of Patients to RCTs: Lessons from Trials of Acupuncture and Exercise for Low Back Pain in Primary Care.

Authors:  Sally E M Bell-Syer; Lucy N Thorpe; Kate Thomas; Hugh Macpherson
Journal:  Evid Based Complement Alternat Med       Date:  2010-11-01       Impact factor: 2.629

10.  Baseline characteristics and comparability of older multimorbid patients with polypharmacy and general practitioners participating in a randomized controlled primary care trial.

Authors:  Katharina Tabea Jungo; Rahel Meier; Fabio Valeri; Nathalie Schwab; Claudio Schneider; Emily Reeve; Marco Spruit; Matthias Schwenkglenks; Nicolas Rodondi; Sven Streit
Journal:  BMC Fam Pract       Date:  2021-06-22       Impact factor: 2.497
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