Literature DB >> 1670796

Randomised clinical trials with clinician-preferred treatment.

E L Korn1, S Baumrind.   

Abstract

The standard design for randomised clinical trials may be inappropriate when the clinician believes that one of the treatments being tested is superior for the patient, or when the clinician has a preference for one of the treatments. For such instances the suggestion is that the patient is randomly allocated to treatment only when there is clinical disagreement about treatment of choice for that patient, and then the patient is assigned to a clinician who had thought that the regimen allocated is the one most appropriate for that patient.

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Mesh:

Year:  1991        PMID: 1670796     DOI: 10.1016/0140-6736(91)90809-4

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  11 in total

1.  Conducting randomized trials in general practice: methodological and practical issues.

Authors:  E Ward; M King; M Lloyd; P Bower; K Friedli
Journal:  Br J Gen Pract       Date:  1999-11       Impact factor: 5.386

2.  How can we tell if a treatment works? Further thoughts on the randomized controlled trial.

Authors:  R P Heaney
Journal:  Osteoporos Int       Date:  1991-09       Impact factor: 4.507

3.  Why we need observational studies to evaluate the effectiveness of health care.

Authors:  N Black
Journal:  BMJ       Date:  1996-05-11

4.  The statistical pitfalls of the partially randomized preference design in non-blinded trials of psychological interventions.

Authors:  Isla Gemmell; Graham Dunn
Journal:  Int J Methods Psychiatr Res       Date:  2011-03       Impact factor: 4.035

5.  Equipoise and the ethics of randomization.

Authors:  R J Lilford; J Jackson
Journal:  J R Soc Med       Date:  1995-10       Impact factor: 5.344

6.  Patient's preference and randomization: new paradigm of evidence-based clinical research.

Authors:  Bertrand Millat; Frédéric Borie; Abe Fingerhut
Journal:  World J Surg       Date:  2005-05       Impact factor: 3.352

7.  Patients' perception of the informed consent process for neurooncology clinical trials.

Authors:  Eva Knifed; Nir Lipsman; Warren Mason; Mark Bernstein
Journal:  Neuro Oncol       Date:  2008-04-03       Impact factor: 12.300

8.  Physicians' preferences for active-controlled versus placebo-controlled trials of new antihypertensive drugs.

Authors:  Scott D Halpern; Peter A Ubel; Jesse A Berlin; Raymond R Townsend; David A Asch
Journal:  J Gen Intern Med       Date:  2002-09       Impact factor: 5.128

Review 9.  Can unequal be more fair? Ethics, subject allocation, and randomised clinical trials.

Authors:  A L Avins
Journal:  J Med Ethics       Date:  1998-12       Impact factor: 2.903

10.  Trial of intensive compared with weekly speech therapy in preschool children.

Authors:  J Barratt; P Littlejohns; J Thompson
Journal:  Arch Dis Child       Date:  1992-01       Impact factor: 3.791

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