Literature DB >> 10818239

Pairing of oligosaccharides in the Fc region of immunoglobulin G.

K Masuda1, Y Yamaguchi, K Kato, N Takahashi, I Shimada, Y Arata.   

Abstract

The Fc portion of immunoglobulin G (IgG) expresses paired oligosaccharides with microheterogeneities, which are associated with efficiencies of effector functions and with pathological states. A comparison of electrospray ionization mass spectrometry data obtained using a variety of Fc fragments derived from human and mouse IgG that do and do not retain the inter-chain disulfide bridge(s) revealed that (1) the Fc portion can be asymmetric as well as symmetric with respect to glycosylation and (2) the ratios of the individual glycoforms are different from what is expected from the random pairing.

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Year:  2000        PMID： 10818239     DOI： 10.1016/s0014-5793(00)01557-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

Review 1.  The role of sialic acid as a modulator of the anti-inflammatory activity of IgG.

Authors:  Sybille Böhm; Inessa Schwab; Anja Lux; Falk Nimmerjahn
Journal:  Semin Immunopathol       Date:  2012-03-22       Impact factor: 9.623

2.  Trap for MAbs: characterization of intact monoclonal antibodies using reversed-phase HPLC on-line with ion-trap mass spectrometry.

Authors:  John C Le; Pavel V Bondarenko
Journal:  J Am Soc Mass Spectrom       Date:  2005-03       Impact factor: 3.109

3.  Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-Orbitrap mass spectrometer.

Authors:  Pavel V Bondarenko; Tonya P Second; Vlad Zabrouskov; Alexander A Makarov; Zhongqi Zhang
Journal:  J Am Soc Mass Spectrom       Date:  2009-03-28       Impact factor: 3.109

4.  Comparison of LC and LC/MS methods for quantifying N-glycosylation in recombinant IgGs.

Authors:  Sandipan Sinha; Gary Pipes; Elizabeth M Topp; Pavel V Bondarenko; Michael J Treuheit; Himanshu S Gadgil
Journal:  J Am Soc Mass Spectrom       Date:  2008-07-16       Impact factor: 3.109

5.  Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.

Authors:  Carola W N Damen; Weibin Chen; Asish B Chakraborty; Mike van Oosterhout; Jeffrey R Mazzeo; John C Gebler; Jan H M Schellens; Hilde Rosing; Jos H Beijnen
Journal:  J Am Soc Mass Spectrom       Date:  2009-08-07       Impact factor: 3.109

6.  Processing of complex N-glycans in IgG Fc-region is affected by core fucosylation.

Authors:  Alexandra Castilho; Clemens Gruber; Andreas Thader; Chris Oostenbrink; Maria Pechlaner; Herta Steinkellner; Friedrich Altmann
Journal:  MAbs       Date:  2015       Impact factor: 5.857

Review 7.  Assessing monoclonal antibody product quality attribute criticality through clinical studies.

Authors:  Andrew M Goetze; Matthew R Schenauer; Gregory C Flynn
Journal:  MAbs       Date:  2010-09-01       Impact factor: 5.857

Review 8.  A perspective on the structure and receptor binding properties of immunoglobulin G Fc.

Authors:  Quinlin M Hanson; Adam W Barb
Journal:  Biochemistry       Date:  2015-05-07       Impact factor: 3.162

Review 9.  Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?

Authors:  Michaela Seeling; Christin Brückner; Falk Nimmerjahn
Journal:  Nat Rev Rheumatol       Date:  2017-09-14       Impact factor: 20.543

10.  New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2.1-A resolution.

Authors:  Petr Kolenko; Jan Dohnálek; Jarmila Dusková; Tereza Skálová; Renata Collard; Jindrich Hasek
Journal:  Immunology       Date:  2008-09-06       Impact factor: 7.397
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