OBJECTIVE: To test the interrater reliability of the Clinical Dementia Rating (CDR) in a multicenter clinical trial. DESIGN: Observational study. SETTING: Training session for a multicenter trial of milameline, a direct muscarinic agonist, in the treatment of Alzheimer's disease. PARTICIPANTS: Twenty-four raters (physicians and nurses) familiar with drug trials and expert in the care of patients with Alzheimer's disease. METHODS: Independent scoring of the CDR using four videotaped CDR interviews. OUTCOME MEASURE: Interrater reliability, as tested by the Kappa statistic RESULTS: The overall interrater reliability was 0.62. Within the CDR domains, the global kappas ranged from 0.33 +/- 0.06 to 0.88 +/- 0.06. CONCLUSIONS: The data support moderate to high overall interrater reliability but show important difficulties in the reliable assessment of early dementia.
OBJECTIVE: To test the interrater reliability of the Clinical Dementia Rating (CDR) in a multicenter clinical trial. DESIGN: Observational study. SETTING: Training session for a multicenter trial of milameline, a direct muscarinic agonist, in the treatment of Alzheimer's disease. PARTICIPANTS: Twenty-four raters (physicians and nurses) familiar with drug trials and expert in the care of patients with Alzheimer's disease. METHODS: Independent scoring of the CDR using four videotaped CDR interviews. OUTCOME MEASURE: Interrater reliability, as tested by the Kappa statistic RESULTS: The overall interrater reliability was 0.62. Within the CDR domains, the global kappas ranged from 0.33 +/- 0.06 to 0.88 +/- 0.06. CONCLUSIONS: The data support moderate to high overall interrater reliability but show important difficulties in the reliable assessment of early dementia.
Authors: James E Galvin; Thomas M Meuser; Mary A Coats; Donald A Bakal; John C Morris Journal: Alzheimer Dis Assoc Disord Date: 2009 Jan-Mar Impact factor: 2.703
Authors: Ranjan Duara; David A Loewenstein; Maria T Greig-Custo; Ashok Raj; Warren Barker; Elizabeth Potter; Elizabeth Schofield; Brent Small; John Schinka; Yougui Wu; Huntington Potter Journal: Int J Geriatr Psychiatry Date: 2010-03 Impact factor: 3.485
Authors: Paul B Rosenberg; Michelle M Mielke; Brian S Appleby; Esther S Oh; Yonas E Geda; Constantine G Lyketsos Journal: Am J Geriatr Psychiatry Date: 2013-02-06 Impact factor: 4.105
Authors: Leslie S Gaynor; Rosie E Curiel Cid; Ailyn Penate; Mónica Rosselli; Sara N Burke; Meredith Wicklund; David A Loewenstein; Russell M Bauer Journal: J Int Neuropsychol Soc Date: 2019-08 Impact factor: 2.892
Authors: Jill K Morris; Eric D Vidoni; Jonathan D Mahnken; Robert N Montgomery; David K Johnson; John P Thyfault; Jeffrey M Burns Journal: Neurobiol Aging Date: 2015-12-01 Impact factor: 4.673
Authors: David R Weir; Robert B Wallace; Kenneth M Langa; Brenda L Plassman; Robert S Wilson; David A Bennett; Ranjan Duara; David Loewenstein; Mary Ganguli; Mary Sano Journal: Alzheimers Dement Date: 2011-01 Impact factor: 21.566
Authors: Linda L Chao; Shannon T Buckley; John Kornak; Norbert Schuff; Catherine Madison; Kristine Yaffe; Bruce L Miller; Joel H Kramer; Michael W Weiner Journal: Alzheimer Dis Assoc Disord Date: 2010 Jan-Mar Impact factor: 2.703