Leslie S Gaynor1, Rosie E Curiel Cid2,3, Ailyn Penate4, Mónica Rosselli3,5, Sara N Burke3,6, Meredith Wicklund3,7, David A Loewenstein2,3, Russell M Bauer1,3. 1. Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA. 2. Department of Psychiatry and Center for Cognitive Neuroscience and Aging, University of Miami Miller School of Medicine, Miami, FL, USA. 3. Florida Alzheimer's Disease Research Center, Gainesville, FL, USA. 4. Wien Center for Alzheimer's Disease and Memory Disorders, Miami Beach, FL, USA. 5. Department of Psychology, Florida Atlantic University, Boca Raton, FL, USA. 6. McKnight Brain Institute and Department of Neuroscience, University of Florida, Gainesville, FL, USA. 7. Department of Neurology, University of Florida College of Medicine, University of Florida, Gainesville, FL, USA.
Abstract
OBJECTIVE: Detection of cognitive impairment suggestive of risk for Alzheimer's disease (AD) progression is crucial to the prevention of incipient dementia. This study was performed to determine if performance on a novel object discrimination task improved identification of earlier deficits in older adults at risk for AD. METHOD: In total, 135 participants from the 1Florida Alzheimer's Disease Research Center [cognitively normal (CN), Pre-mild cognitive impairment (PreMCI), amnestic mild cognitive impairment (aMCI), and dementia] completed a test of object discrimination and traditional memory measures in the context of a larger neuropsychological and clinical evaluation. RESULTS: The Object Recognition and Discrimination Task (ORDT) revealed significant differences between the PreMCI, aMCI, and dementia groups versus CN individuals. Moreover, relative risk of being classified as PreMCI rather than CN increased as an inverse function of ORDT score. DISCUSSION: Overall, the obtained results suggest that a novel object discrimination task improves the detection of very early AD-related cognitive impairment, increasing the window for therapeutic intervention. (JINS, 2019, 25, 688-698).
OBJECTIVE: Detection of cognitive impairment suggestive of risk for Alzheimer's disease (AD) progression is crucial to the prevention of incipient dementia. This study was performed to determine if performance on a novel object discrimination task improved identification of earlier deficits in older adults at risk for AD. METHOD: In total, 135 participants from the 1Florida Alzheimer's Disease Research Center [cognitively normal (CN), Pre-mild cognitive impairment (PreMCI), amnestic mild cognitive impairment (aMCI), and dementia] completed a test of object discrimination and traditional memory measures in the context of a larger neuropsychological and clinical evaluation. RESULTS: The Object Recognition and Discrimination Task (ORDT) revealed significant differences between the PreMCI, aMCI, and dementia groups versus CN individuals. Moreover, relative risk of being classified as PreMCI rather than CN increased as an inverse function of ORDT score. DISCUSSION: Overall, the obtained results suggest that a novel object discrimination task improves the detection of very early AD-related cognitive impairment, increasing the window for therapeutic intervention. (JINS, 2019, 25, 688-698).
Authors: Omar Gurrola Arambula; Flavia Helena Pereira Padovani; Jose Eduardo Corrente; Andreas Batista Schelp; Felipe Jacques Sanches; Rogerio Martins Amorim; Arthur Oscar Schelp Journal: Dement Neuropsychol Date: 2021 Jul-Sep
Authors: Andrea Castegnaro; David Howett; Adrienne Li; Elizabeth Harding; Dennis Chan; Neil Burgess; John King Journal: Hippocampus Date: 2022-08-02 Impact factor: 3.753