Literature DB >> 10809711

Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity.

D P Letley1, J C Atherton.   

Abstract

Naturally occurring noncytotoxic vacA type s2 strains of Helicobacter pylori have a 12-residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic type s1 strains. We show that adding the region encoding this extension to type s1 vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA production.

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Year:  2000        PMID： 10809711      PMCID： PMC94518          DOI： 10.1128/JB.182.11.3278-3280.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  7 in total

1.  Vacuolating cytotoxin (vacA) alleles of Helicobacter pylori comprise two geographically widespread types, m1 and m2, and have evolved through limited recombination.

Authors:  J C Atherton; P M Sharp; T L Cover; G Gonzalez-Valencia; R M Peek; S A Thompson; C J Hawkey; M J Blaser
Journal:  Curr Microbiol       Date:  1999-10       Impact factor: 2.188

2.  Identification of the minimal intracellular vacuolating domain of the Helicobacter pylori vacuolating toxin.

Authors:  D Ye; D C Willhite; S R Blanke
Journal:  J Biol Chem       Date:  1999-04-02       Impact factor: 5.157

3.  Identification of the Helicobacter pylori VacA toxin domain active in the cell cytosol.

Authors:  M de Bernard; D Burroni; E Papini; R Rappuoli; J Telford; C Montecucco
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

4.  Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.

Authors:  J C Atherton; R M Peek; K T Tham; T L Cover; M J Blaser
Journal:  Gastroenterology       Date:  1997-01       Impact factor: 22.682

5.  Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

Authors:  T L Cover; M K Tummuru; P Cao; S A Thompson; M J Blaser
Journal:  J Biol Chem       Date:  1994-04-08       Impact factor: 5.157

6.  Free recombination within Helicobacter pylori.

Authors:  S Suerbaum; J M Smith; K Bapumia; G Morelli; N H Smith; E Kunstmann; I Dyrek; M Achtman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-13       Impact factor: 11.205

7.  Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.

Authors:  J C Atherton; P Cao; R M Peek; M K Tummuru; M J Blaser; T L Cover
Journal:  J Biol Chem       Date:  1995-07-28       Impact factor: 5.157
  7 in total
  37 in total

1.  Evolution of the Helicobacter pylori vacuolating cytotoxin in a human stomach.

Authors:  Francisco Aviles-Jimenez; Darren P Letley; Gerardo Gonzalez-Valencia; Nina Salama; Javier Torres; John C Atherton
Journal:  J Bacteriol       Date:  2004-08       Impact factor: 3.490

Review 2.  Type V protein secretion pathway: the autotransporter story.

Authors:  Ian R Henderson; Fernando Navarro-Garcia; Mickaël Desvaux; Rachel C Fernandez; Dlawer Ala'Aldeen
Journal:  Microbiol Mol Biol Rev       Date:  2004-12       Impact factor: 11.056

3.  Association of nonsynonymous substitutions in the intermediate region of the vacA gene of Helicobacter pylori with gastric diseases in Taiwan.

Authors:  Shew-Meei Sheu; Kuei-Hsiang Hung; Bor-Shyang Sheu; Hsiao-Bai Yang; Jiunn-Jong Wu
Journal:  J Clin Microbiol       Date:  2008-11-19       Impact factor: 5.948

4.  Helicobacter pylori vacA s1a and s1b alleles from clinical isolates from different regions of Chile show a distinct geographic distribution.

Authors:  M I Diaz; A Valdivia; P Martinez; J L Palacios; P Harris; J Novales; E Garrido; D Valderrama; C Shilling; A Kirberg; E Hebel; J Fierro; R Bravo; F Siegel; G Leon; G Klapp; A Venegas
Journal:  World J Gastroenterol       Date:  2005-10-28       Impact factor: 5.742

Review 5.  Second and third line treatment options for Helicobacter pylori eradication.

Authors:  Mingjun Song; Tiing Leong Ang
Journal:  World J Gastroenterol       Date:  2014-02-14       Impact factor: 5.742

6.  Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study.

Authors:  Ameer A Memon; Nawfal R Hussein; Véronique Y Miendje Deyi; Alain Burette; John C Atherton
Journal:  J Clin Microbiol       Date:  2014-06-11       Impact factor: 5.948

7.  A novel method for genotyping the Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens.

Authors:  Rui M Ferreira; Jose C Machado; Darren Letley; John C Atherton; Maria L Pardo; Carlos A Gonzalez; Fatima Carneiro; Ceu Figueiredo
Journal:  J Clin Microbiol       Date:  2012-10-03       Impact factor: 5.948

Review 8.  Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease.

Authors:  Dacie R Bridge; D Scott Merrell
Journal:  Gut Microbes       Date:  2013-02-04

9.  Epidemiological link between gastric disease and polymorphisms in VacA and CagA.

Authors:  Sungil Jang; Kathleen R Jones; Cara H Olsen; Young Min Joo; Yun-Jung Yoo; In-Sik Chung; Jeong-Heon Cha; D Scott Merrell
Journal:  J Clin Microbiol       Date:  2009-12-02       Impact factor: 5.948

Review 10.  Virulence factor genotypes of Helicobacter pylori affect cure rates of eradication therapy.

Authors:  Mitsushige Sugimoto; Yoshio Yamaoka
Journal:  Arch Immunol Ther Exp (Warsz)       Date:  2009-02-14       Impact factor: 4.291
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