Literature DB >> 9770535

Free recombination within Helicobacter pylori.

S Suerbaum1, J M Smith, K Bapumia, G Morelli, N H Smith, E Kunstmann, I Dyrek, M Achtman.   

Abstract

Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage equilibrium by using the Homoplasy Test and compatibility matrices. Horizontal genetic exchange in H. pylori is so frequent that different loci and polymorphisms within each locus are all at linkage equilibrium. These results indicate that H. pylori is panmictic. Comparisons with sequences from Escherichia coli, Neisseria meningitidis, and Drosophila melanogaster showed that recombination in H. pylori was much more frequent than in other species. In contrast, when multiple family members infected with H. pylori were investigated, some strains were indistinguishable at all three loci. Thus, H. pylori is clonal over short time periods after natural transmission.

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Year:  1998        PMID： 9770535      PMCID： PMC22880          DOI： 10.1073/pnas.95.21.12619

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  41 in total

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Journal:  Genetics       Date:  1990-11       Impact factor: 4.562

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Authors:  J Maynard Smith; N H Smith
Journal:  Mol Biol Evol       Date:  1998-05       Impact factor: 16.240

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Journal:  Microb Pathog       Date:  1987-07       Impact factor: 3.738

5.  Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica.

Authors:  E F Boyd; K Nelson; F S Wang; T S Whittam; R K Selander
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

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Authors:  D S Guttman; D E Dykhuizen
Journal:  Genetics       Date:  1994-12       Impact factor: 4.562

7.  Clonal divergence in Escherichia coli as a result of recombination, not mutation.

Authors:  D S Guttman; D E Dykhuizen
Journal:  Science       Date:  1994-11-25       Impact factor: 47.728

8.  Amino acid polymorphisms for esterase-6 in Drosophila melanogaster.

Authors:  P H Cooke; J G Oakeshott
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

9.  Genotypical variation of Campylobacter pylori from gastric mucosa.

Authors:  J H Oudbier; W Langenberg; E A Rauws; C Bruin-Mosch
Journal:  J Clin Microbiol       Date:  1990-03       Impact factor: 5.948

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Authors:  S I Majewski; C S Goodwin
Journal:  J Infect Dis       Date:  1988-03       Impact factor: 5.226
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  246 in total

1.  The detection and measurement of recombination from sequence data.

Authors:  J M Smith
Journal:  Genetics       Date:  1999-10       Impact factor: 4.562

2.  Recombination within natural populations of pathogenic bacteria: short-term empirical estimates and long-term phylogenetic consequences.

Authors:  E J Feil; E C Holmes; D E Bessen; M S Chan; N P Day; M C Enright; R Goldstein; D W Hood; A Kalia; C E Moore; J Zhou; B G Spratt
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-02       Impact factor: 11.205

3.  Genetic isolation of meningococci of the electrophoretic type 37 complex.

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Authors:  J C Atherton; P M Sharp; T L Cover; G Gonzalez-Valencia; R M Peek; S A Thompson; C J Hawkey; M J Blaser
Journal:  Curr Microbiol       Date:  1999-10       Impact factor: 2.188

5.  Estimating recombinational parameters in Streptococcus pneumoniae from multilocus sequence typing data.

Authors:  E J Feil; J M Smith; M C Enright; B G Spratt
Journal:  Genetics       Date:  2000-04       Impact factor: 4.562

6.  Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity.

Authors:  D P Letley; J C Atherton
Journal:  J Bacteriol       Date:  2000-06       Impact factor: 3.490

7.  Calibrating bacterial evolution.

Authors:  H Ochman; S Elwyn; N A Moran
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

8.  A coalescent-based method for detecting and estimating recombination from gene sequences.

Authors:  Gil McVean; Philip Awadalla; Paul Fearnhead
Journal:  Genetics       Date:  2002-03       Impact factor: 4.562

9.  Phenotypic and genotypic variation in methylases involved in type II restriction-modification systems in Helicobacter pylori.

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Journal:  Nucleic Acids Res       Date:  2002-06-01       Impact factor: 16.971

10.  Mutators and sex in bacteria: conflict between adaptive strategies.

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Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205
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