Literature DB >> 19020071

Association of nonsynonymous substitutions in the intermediate region of the vacA gene of Helicobacter pylori with gastric diseases in Taiwan.

Shew-Meei Sheu1, Kuei-Hsiang Hung, Bor-Shyang Sheu, Hsiao-Bai Yang, Jiunn-Jong Wu.   

Abstract

The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGITSSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the i1-type cluster C sequence could be a marker of VacA in the Taiwanese strains.

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Year:  2008        PMID： 19020071      PMCID： PMC2620866          DOI： 10.1128/JCM.01651-08

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  18 in total

1.  Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity.

Authors:  D P Letley; J C Atherton
Journal:  J Bacteriol       Date:  2000-06       Impact factor: 3.490

2.  Presence of iceA1 but not cagA, cagC, cagE, cagF, cagN, cagT, or orf13 genes of Helicobacter pylori is associated with more severe gastric inflammation in Taiwanese.

Authors:  Shew-Meei Sheu; Bor-Shyang Sheu; Hsiao-Bai Yang; Ching Li; Tro-Chen Chu; Jiunn-Jong Wu
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3.  Identification and analysis of a new vacA genotype variant of Helicobacter pylori in different patient groups in Germany.

Authors:  S Strobel; S Bereswill; P Balig; P Allgaier; H G Sonntag; M Kist
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Review 4.  Cancer epidemiology and control in Taiwan: a brief review.

Authors:  Chien-Jen Chen; San-Lin You; Lih-Hwa Lin; Wan-Lun Hsu; Ya-Wen Yang
Journal:  Jpn J Clin Oncol       Date:  2002-03       Impact factor: 3.019

5.  A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation.

Authors:  M S McClain; P Cao; H Iwamoto; A D Vinion-Dubiel; G Szabo; Z Shao; T L Cover
Journal:  J Bacteriol       Date:  2001-11       Impact factor: 3.490

6.  Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.

Authors:  J C Atherton; R M Peek; K T Tham; T L Cover; M J Blaser
Journal:  Gastroenterology       Date:  1997-01       Impact factor: 22.682

Review 7.  Helicobacter pylori.

Authors:  B E Dunn; H Cohen; M J Blaser
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Journal:  Gastroenterology       Date:  2008-03-25       Impact factor: 22.682

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Authors:  J C Atherton; P Cao; R M Peek; M K Tummuru; M J Blaser; T L Cover
Journal:  J Biol Chem       Date:  1995-07-28       Impact factor: 5.157

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  9 in total

1.  Polymorphisms in the intermediate region of VacA impact Helicobacter pylori-induced disease development.

Authors:  Kathleen R Jones; Sungil Jang; Jennifer Y Chang; Jinmoon Kim; In-Sik Chung; Cara H Olsen; D Scott Merrell; Jeong-Heon Cha
Journal:  J Clin Microbiol       Date:  2010-11-17       Impact factor: 5.948

2.  The cag PAI is intact and functional but HP0521 varies significantly in Helicobacter pylori isolates from Malaysia and Singapore.

Authors:  H-M A Schmidt; S Andres; C Nilsson; Z Kovach; N O Kaakoush; L Engstrand; K-L Goh; K M Fock; D Forman; H Mitchell
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-02-16       Impact factor: 3.267

3.  Epidemiological link between gastric disease and polymorphisms in VacA and CagA.

Authors:  Sungil Jang; Kathleen R Jones; Cara H Olsen; Young Min Joo; Yun-Jung Yoo; In-Sik Chung; Jeong-Heon Cha; D Scott Merrell
Journal:  J Clin Microbiol       Date:  2009-12-02       Impact factor: 5.948

4.  The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay.

Authors:  Christian González-Rivera; Holly M Scott Algood; Jana N Radin; Mark S McClain; Timothy L Cover
Journal:  Infect Immun       Date:  2012-05-14       Impact factor: 3.441

5.  Prevalence of Specific Helicobacter PyloricagA, vacA, iceA, ureC Genotypes and its Clinical Relevance in the Patients with Acid-Peptic Diseases.

Authors:  Himani Bhardwaj Pandya; Harihar Hardas Agravat; Jagdish Shantilal Patel
Journal:  J Clin Diagn Res       Date:  2017-08-01

6.  Association between cagA and vacA genotypes and pathogenesis in a Helicobacter pylori infected population from South-eastern Sweden.

Authors:  Anneli Karlsson; Anna Ryberg; Marjan Nosouhi Dehnoei; Kurt Borch; Hans-Jürg Monstein
Journal:  BMC Microbiol       Date:  2012-07-02       Impact factor: 3.605

7.  Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection.

Authors:  Yu-Ching Tsai; Wei-Hsin Hsiao; Sheng-Hsiang Lin; Hsiao-Bai Yang; Hsiu-Chi Cheng; Wei-Lun Chang; Cheng-Chan Lu; Bor-Shyang Sheu
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8.  High Frequency of vacA s1m2 Genotypes Among Helicobacter pylori Isolates From Patients With Gastroduodenal Disorders in Kermanshah, Iran.

Authors:  Hamid Pajavand; Amirhooshang Alvandi; Parviz Mohajeri; Somaye Bakhtyari; Homayoon Bashiri; Behnam Kalali; Markus Gerhard; Farid Najafi; Ramin Abiri
Journal:  Jundishapur J Microbiol       Date:  2015-11-22       Impact factor: 0.747

9.  Prevalence of Helicobacter pylori vacA different genotypes in Isfahan, Iran.

Authors:  S Asghar Havaei; Parviz Mohajeri; Reza Khashei; Rasoul Salehi; Hamid Tavakoli
Journal:  Adv Biomed Res       Date:  2014-01-24
  9 in total

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