| Literature DB >> 10799620 |
Abstract
The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns.Entities:
Mesh:
Year: 2000 PMID: 10799620 PMCID: PMC110898 DOI: 10.1128/jvi.74.11.5385-5387.2000
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103