PURPOSE: To estimate and compare the fractional distribution volume (fDV) of gadodiamide injection and technetium 99m-diethylenetriaminepentaacetic acid (DTPA) in the reperfused myocardium of rat hearts subjected to various durations of ischemia. MATERIALS AND METHODS: Magnetic resonance (MR) imaging and autoradiography were performed in rats subjected to 20, 30, 40, or 60 minutes of regional ischemia followed by 1 hour of reperfusion. The fDVs of gadodiamide injection and (99m)Tc-DTPA were measured and compared by using inversion-recovery echo-planar imaging and autoradiographic phosphor imaging, respectively. RESULTS: The mean fDV of both tracers (gadodiamide and (99m)Tc-DTPA) in normal myocardium was 18% +/- 1, whereas that in the entire area at risk increased significantly (P <.05) with 20, 30, 40, and 60 minutes of ischemia to 32% +/- 1, 57% +/- 4, 66% +/- 2, and 68% +/- 2, respectively. The fDV was significantly (P <.05) greater in the core of infarction-78% +/- 4, 89% +/- 5, and 88% +/- 5 with 30, 40, and 60 minutes of ischemia, respectively-than in the normal myocardium or in the area at risk. CONCLUSION: The fDV of MR contrast material in the periinfarcted rim was significantly (P <. 05) greater than that in the normal myocardium, but significantly less than that in the core of infarcted myocardium.
PURPOSE: To estimate and compare the fractional distribution volume (fDV) of gadodiamide injection and technetium 99m-diethylenetriaminepentaacetic acid (DTPA) in the reperfused myocardium of rat hearts subjected to various durations of ischemia. MATERIALS AND METHODS: Magnetic resonance (MR) imaging and autoradiography were performed in rats subjected to 20, 30, 40, or 60 minutes of regional ischemia followed by 1 hour of reperfusion. The fDVs of gadodiamide injection and (99m)Tc-DTPA were measured and compared by using inversion-recovery echo-planar imaging and autoradiographic phosphor imaging, respectively. RESULTS: The mean fDV of both tracers (gadodiamide and (99m)Tc-DTPA) in normal myocardium was 18% +/- 1, whereas that in the entire area at risk increased significantly (P <.05) with 20, 30, 40, and 60 minutes of ischemia to 32% +/- 1, 57% +/- 4, 66% +/- 2, and 68% +/- 2, respectively. The fDV was significantly (P <.05) greater in the core of infarction-78% +/- 4, 89% +/- 5, and 88% +/- 5 with 30, 40, and 60 minutes of ischemia, respectively-than in the normal myocardium or in the area at risk. CONCLUSION: The fDV of MR contrast material in the periinfarcted rim was significantly (P <. 05) greater than that in the normal myocardium, but significantly less than that in the core of infarcted myocardium.
Authors: Marcelo Souto Nacif; Evrim B Turkbey; Neville Gai; Saman Nazarian; Rob J van der Geest; Radwa A Noureldin; Christopher T Sibley; Martin Ugander; Songtao Liu; Andrew E Arai; João A C Lima; David A Bluemke Journal: J Magn Reson Imaging Date: 2011-09-23 Impact factor: 4.813
Authors: Sophia Hammer-Hansen; Steve W Leung; Li-Yueh Hsu; Joel R Wilson; Joni Taylor; Anders M Greve; Jens Jakob Thune; Lars Køber; Peter Kellman; Andrew E Arai Journal: JACC Cardiovasc Imaging Date: 2016-09-21
Authors: Jong Min Park; Yeon Hyeon Choe; Samuel Chang; Yon Mi Sung; Seok Seon Kang; Min Joo Kim; Boo-Kyung Han; Sang-Hee Choi Journal: Korean J Radiol Date: 2004 Jan-Mar Impact factor: 3.500
Authors: Erik Hedström; Henrik Engblom; Fredrik Frogner; Karin Aström-Olsson; Hans Ohlin; Stefan Jovinge; Håkan Arheden Journal: J Cardiovasc Magn Reson Date: 2009-09-23 Impact factor: 5.364