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Literature DB >> 10786633

A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.

K C Neal¹, A Pannuti, E R Smith, J C Lucchesi.

Abstract

We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. Based on hMOF's chromodomain, we discuss possible interactions with other proteins.

Entities: Gene Species

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Year: 2000 PMID： 10786633 DOI： 10.1016/s0167-4781(99)00211-0

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

29 in total

1. Targeting the chromatin-remodeling MSL complex of Drosophila to its sites of action on the X chromosome requires both acetyl transferase and ATPase activities.

Authors: W Gu; X Wei; A Pannuti; J C Lucchesi
Journal: EMBO J Date: 2000-10-02 Impact factor: 11.598

2. The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster.

Authors: Manika P Bhadra; Nobuo Horikoshi; Sreerangam N C V L Pushpavallipvalli; Arpita Sarkar; Indira Bag; Anita Krishnan; John C Lucchesi; Rakesh Kumar; Qin Yang; Raj K Pandita; Mayank Singh; Utpal Bhadra; Joel C Eissenberg; Tej K Pandita
Journal: Chromosoma Date: 2011-11-10 Impact factor: 4.316

3. MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

Authors: Girdhar G Sharma; Sairei So; Arun Gupta; Rakesh Kumar; Christelle Cayrou; Nikita Avvakumov; Utpal Bhadra; Raj K Pandita; Matthew H Porteus; David J Chen; Jacques Cote; Tej K Pandita
Journal: Mol Cell Biol Date: 2010-05-17 Impact factor: 4.272

10. Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation.

Authors: Sandra N Garcia; Bhakti M Kirtane; Andrej J Podlutsky; Olivia M Pereira-Smith; Kaoru Tominaga
Journal: FEBS Lett Date: 2007-10-18 Impact factor: 4.124

A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.

1. Targeting the chromatin-remodeling MSL complex of Drosophila to its sites of action on the X chromosome requires both acetyl transferase and ATPase activities.

2. The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster.

3. MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

4. Homozygous disruption of the Tip60 gene causes early embryonic lethality.

Review 5. Dosage Compensation in Drosophila-a Model for the Coordinate Regulation of Transcription.

6. Structure and function of histone acetyltransferase MOF.

7. MRG15 regulates embryonic development and cell proliferation.

8. Involvement of human MOF in ATM function.

9. MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii.

10. Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation.