Literature DB >> 28503659

Structure and function of histone acetyltransferase MOF.

Qiao Yi Chen1, Max Costa1, Hong Sun1.   

Abstract

MOF was first identified in Drosophila melanogaster as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and similar enzymatic activities. MOF plays important roles in dosage compensation, ESC self-renewal, DNA damage and repair, cell survival, and gene expression regulation. Dysregulation of MOF has been implicated in tumor formation and progression of many types of human cancers. This review will discuss the structure and activity of mammalian hMOF as well as its function in H4K16 acetylation, DNA damage response, stem cell pluripotency, and carcinogenesis.

Entities:  

Keywords:  H4K16; MOF; MSL; NSL; histone acetylation

Year:  2015        PMID： 28503659      PMCID： PMC5425159          DOI： 10.3934/biophy.2015.4.555

Source DB:  PubMed          Journal:  AIMS Biophys        ISSN： 2377-9098


  76 in total

1.  Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila.

Authors:  A Akhtar; P B Becker
Journal:  Mol Cell       Date:  2000-02       Impact factor: 17.970

2.  Functional integration of the histone acetyltransferase MOF into the dosage compensation complex.

Authors:  Violette Morales; Tobias Straub; Martin F Neumann; Gabrielle Mengus; Asifa Akhtar; Peter B Becker
Journal:  EMBO J       Date:  2004-05-13       Impact factor: 11.598

Review 3.  Regulation of DNA repair throughout the cell cycle.

Authors:  Dana Branzei; Marco Foiani
Journal:  Nat Rev Mol Cell Biol       Date:  2008-02-20       Impact factor: 94.444

4.  Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1.

Authors:  Jan Kadlec; Erinc Hallacli; Michael Lipp; Herbert Holz; Juan Sanchez-Weatherby; Stephen Cusack; Asifa Akhtar
Journal:  Nat Struct Mol Biol       Date:  2011-01-09       Impact factor: 15.369

5.  MYST protein acetyltransferase activity requires active site lysine autoacetylation.

Authors:  Hua Yuan; Dorine Rossetto; Hestia Mellert; Weiwei Dang; Madhusudan Srinivasan; Jamel Johnson; Santosh Hodawadekar; Emily C Ding; Kaye Speicher; Nebiyu Abshiru; Rocco Perry; Jiang Wu; Chao Yang; Y George Zheng; David W Speicher; Pierre Thibault; Alain Verreault; F Bradley Johnson; Shelley L Berger; Rolf Sternglanz; Steven B McMahon; Jacques Côté; Ronen Marmorstein
Journal:  EMBO J       Date:  2011-10-21       Impact factor: 11.598

6.  A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16.

Authors:  Edwin R Smith; Christelle Cayrou; Rong Huang; William S Lane; Jacques Côté; John C Lucchesi
Journal:  Mol Cell Biol       Date:  2005-11       Impact factor: 4.272

7.  Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.

Authors:  Mingbo Cai; Zhenhua Hu; Juanjuan Liu; Jian Gao; Mingzi Tan; Danye Zhang; Liancheng Zhu; Shuice Liu; Rui Hou; Bei Lin
Journal:  Oncol Rep       Date:  2014-12-05       Impact factor: 3.906

8.  hMOF, a KAT(8) with many lives.

Authors:  Hestia S Mellert; Steven B McMahon
Journal:  Mol Cell       Date:  2009-10-23       Impact factor: 17.970

9.  The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset.

Authors:  Christian Feller; Matthias Prestel; Holger Hartmann; Tobias Straub; Johannes Söding; Peter B Becker
Journal:  Nucleic Acids Res       Date:  2011-10-27       Impact factor: 16.971

10.  Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma.

Authors:  Yong Wang; Rui Zhang; Donglu Wu; Zhihua Lu; Wentao Sun; Yong Cai; Chunxi Wang; Jingji Jin
Journal:  J Exp Clin Cancer Res       Date:  2013-02-09
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  4 in total

Review 1.  Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis.

Authors:  Qiao Yi Chen; Anthony Murphy; Hong Sun; Max Costa
Journal:  Toxicol Appl Pharmacol       Date:  2019-06-20       Impact factor: 4.219

2.  Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first).

Authors:  Zhen Han; Hong Wu; Sunjoo Kim; Xiangkun Yang; Qianjin Li; He Huang; Houjian Cai; Michael G Bartlett; Aiping Dong; Hong Zeng; Peter J Brown; Xiang-Jiao Yang; Cheryl H Arrowsmith; Yingming Zhao; Y George Zheng
Journal:  J Biol Chem       Date:  2018-01-10       Impact factor: 5.157

3.  Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases.

Authors:  Maria Oczkowicz; Tomasz Szmatoła; Małgorzata Świątkiewicz; Klaudia Pawlina-Tyszko; Artur Gurgul; Tomasz Ząbek
Journal:  BMC Genomics       Date:  2018-12-03       Impact factor: 3.969

Review 4.  BAZ1B the Protean Protein.

Authors:  Shahin Behrouz Sharif; Nina Zamani; Brian P Chadwick
Journal:  Genes (Basel)       Date:  2021-09-28       Impact factor: 4.096
  4 in total

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