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Literature DB >> 17961556

Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation.

Sandra N Garcia¹, Bhakti M Kirtane, Andrej J Podlutsky, Olivia M Pereira-Smith, Kaoru Tominaga.

Abstract

MORF4-related gene on chromosome 15 (MRG15) is a core component of the NuA4/Tip60 histone acetyltransferase complex that modifies chromatin structure. We here demonstrate that Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit an impaired DNA-damage response post gamma irradiation, when compared to wild-type cells. Defects in DNA-repair and cell growth, and delayed recruitment of repair proteins to sites of damage were observed. Formation of phosphorylated H2AX and 53BP1 foci was delayed in Mrg15 mutant versus wild-type cells following irradiation. These data implicate a novel role for MRG15 in DNA-damage repair in mammalian cells.

Entities: Gene Species

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Year: 2007 PMID： 17961556 PMCID： PMC2132445 DOI： 10.1016/j.febslet.2007.10.017

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

24 in total

1. Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae.

Authors: Toyoko Tsukuda; Alastair B Fleming; Jac A Nickoloff; Mary Ann Osley
Journal: Nature Date: 2005-11-17 Impact factor: 49.962

Review 2. Dynamics of chromatin during the repair of DNA double-strand breaks.

Authors: Jessica A Downs; Jacques Côté
Journal: Cell Cycle Date: 2005-10-17 Impact factor: 4.534

3. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

Authors: Yingli Sun; Xiaofeng Jiang; Shujuan Chen; Norvin Fernandes; Brendan D Price
Journal: Proc Natl Acad Sci U S A Date: 2005-09-02 Impact factor: 11.205

4. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks.

Authors: Rabih Murr; Joanna I Loizou; Yun-Gui Yang; Cyrille Cuenin; Hai Li; Zhao-Qi Wang; Zdenko Herceg
Journal: Nat Cell Biol Date: 2005-12-11 Impact factor: 28.824

5. H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks.

Authors: Thomas M Marti; Eli Hefner; Luzviminda Feeney; Valerie Natale; James E Cleaver
Journal: Proc Natl Acad Sci U S A Date: 2006-06-20 Impact factor: 11.205

6. Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.

Authors: M J Bertram; N G Bérubé; X Hang-Swanson; Q Ran; J K Leung; S Bryce; K Spurgers; R J Bick; A Baldini; Y Ning; L J Clark; E K Parkinson; J C Barrett; J R Smith; O M Pereira-Smith
Journal: Mol Cell Biol Date: 1999-02 Impact factor: 4.272

7. Structure of the chromatin binding (chromo) domain from mouse modifier protein 1.

Authors: L J Ball; N V Murzina; R W Broadhurst; A R Raine; S J Archer; F J Stott; A G Murzin; P B Singh; P J Domaille; E D Laue
Journal: EMBO J Date: 1997-05-01 Impact factor: 11.598

8. MRG15 regulates embryonic development and cell proliferation.

Authors: Kaoru Tominaga; Bhakti Kirtane; James G Jackson; Yuji Ikeno; Takayoshi Ikeda; Christina Hawks; James R Smith; Martin M Matzuk; Olivia M Pereira-Smith
Journal: Mol Cell Biol Date: 2005-04 Impact factor: 4.272

9. Involvement of human MOF in ATM function.

Authors: Arun Gupta; Girdhar G Sharma; Charles S H Young; Manjula Agarwal; Edwin R Smith; Tanya T Paull; John C Lucchesi; Kum Kum Khanna; Thomas Ludwig; Tej K Pandita
Journal: Mol Cell Biol Date: 2005-06 Impact factor: 4.272

10. Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions.

Authors: Thomas Kusch; Laurence Florens; W Hayes Macdonald; Selene K Swanson; Robert L Glaser; John R Yates; Susan M Abmayr; Michael P Washburn; Jerry L Workman
Journal: Science Date: 2004-11-04 Impact factor: 47.728

22 in total

Review 1. Emerging role of the MORF/MRG gene family in various biological processes, including aging.

Authors: Meizhen Chen; Kaoru Tominaga; Olivia M Pereira-Smith
Journal: Ann N Y Acad Sci Date: 2010-06 Impact factor: 5.691

2. MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks.

Authors: Tomohiro Hayakawa; Fan Zhang; Noriyo Hayakawa; Yasuko Ohtani; Kaori Shinmyozu; Jun-ichi Nakayama; Paul R Andreassen
Journal: J Cell Sci Date: 2010-04-01 Impact factor: 5.285

Review 3. Regulation of histone modifying enzymes by the ubiquitin-proteasome system.

Authors: Chunbin Zou; Rama K Mallampalli
Journal: Biochim Biophys Acta Date: 2014-01-03

4. MRG15 is a novel PALB2-interacting factor involved in homologous recombination.

Authors: Shirley M-H Sy; Michael S Y Huen; Junjie Chen
Journal: J Biol Chem Date: 2009-06-24 Impact factor: 5.157

5. Histone deacetylase 2 (HDAC2) protein-dependent deacetylation of mortality factor 4-like 1 (MORF4L1) protein enhances its homodimerization.

Authors: Yan Chen; Jin Li; Sarah Dunn; Sheng Xiong; Wei Chen; Yutong Zhao; Bill B Chen; Rama K Mallampalli; Chunbin Zou
Journal: J Biol Chem Date: 2014-01-22 Impact factor: 5.157

10. The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer.

Authors: Zhiwei Chen; Xiangyun Ye; Naiwang Tang; Shengping Shen; Ziming Li; Xiaomin Niu; Shun Lu; Ling Xu
Journal: Br J Pharmacol Date: 2014-07 Impact factor: 8.739