Literature DB >> 10769001

Biochemical and genetic evidence for phospholipase C activity in Mycobacterium ulcerans.

A Gomez1, A Mve-Obiang, B Vray, J Remacle, K Chemlal, W M Meyers, F Portaels, P A Fonteyne.   

Abstract

This study reports the existence of phospholipase C and D enzymatic activities in Mycobacterium ulcerans cultures as determined by use of thin-layer chromatography to detect diglycerides in hydrolysates of radiolabeled phosphatidylcholine. M. ulcerans DNA sequences homologous to the genes encoding phospholipase C in Mycobacterium tuberculosis and Pseudomonas aeruginosa were identified by sequence analysis and DNA-DNA hybridization. Whether or not the phospholipase C and D enzymes of M. ulcerans plays a role in the pathogenesis of the disease needs further investigation.

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Year:  2000        PMID： 10769001      PMCID： PMC97516          DOI： 10.1128/IAI.68.5.2995-2997.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  24 in total

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Authors:  R M Ostroff; A I Vasil; M L Vasil
Journal:  J Bacteriol       Date:  1990-10       Impact factor: 3.490

Review 2.  Proposed minimal standards for the genus Mycobacterium and for description of new slowly growing Mycobacterium species.

Authors:  V V Lévy-Frébault; F Portaels
Journal:  Int J Syst Bacteriol       Date:  1992-04

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Authors:  W T Hockmeyer; R E Krieg; M Reich; R D Johnson
Journal:  Infect Immun       Date:  1978-07       Impact factor: 3.441

4.  A species-specific nucleotide sequence of Mycobacterium tuberculosis encodes a protein that exhibits hemolytic activity when expressed in Escherichia coli.

Authors:  S C Leão; C L Rocha; L A Murillo; C A Parra; M E Patarroyo
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

5.  Targeted mutagenesis of the phospholipase D gene results in decreased virulence of Corynebacterium pseudotuberculosis.

Authors:  P J McNamara; G A Bradley; J G Songer
Journal:  Mol Microbiol       Date:  1994-06       Impact factor: 3.501

6.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

7.  Use of an ordered cosmid library to deduce the genomic organization of Mycobacterium leprae.

Authors:  K Eiglmeier; N Honoré; S A Woods; B Caudron; S T Cole
Journal:  Mol Microbiol       Date:  1993-01       Impact factor: 3.501

8.  Toxic phospholipases D of Corynebacterium pseudotuberculosis, C. ulcerans and Arcanobacterium haemolyticum: cloning and sequence homology.

Authors:  P J McNamara; W A Cuevas; J G Songer
Journal:  Gene       Date:  1995-04-14       Impact factor: 3.688

9.  Insertion element IS986 from Mycobacterium tuberculosis: a useful tool for diagnosis and epidemiology of tuberculosis.

Authors:  P W Hermans; D van Soolingen; J W Dale; A R Schuitema; R A McAdam; D Catty; J D van Embden
Journal:  J Clin Microbiol       Date:  1990-09       Impact factor: 5.948

10.  Expression of contact-dependent cytolytic activity by Mycobacterium tuberculosis and isolation of the genomic locus that encodes the activity.

Authors:  C H King; S Mundayoor; J T Crawford; T M Shinnick
Journal:  Infect Immun       Date:  1993-06       Impact factor: 3.441
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  4 in total

1.  Mycobacterium ulcerans cytotoxicity in an adipose cell model.

Authors:  K M Dobos; P L Small; M Deslauriers; F D Quinn; C H King
Journal:  Infect Immun       Date:  2001-11       Impact factor: 3.441

2.  Detection of phospholipase C in nontuberculous mycobacteria and its possible role in hemolytic activity.

Authors:  A Gomez; A Mve-Obiang; B Vray; W Rudnicka; I C Shamputa; F Portaels; W M Meyers; P A Fonteyne; L Realini
Journal:  J Clin Microbiol       Date:  2001-04       Impact factor: 5.948

3.  Differential production of systemic and intralesional gamma interferon and interleukin-10 in nodular and ulcerative forms of Buruli disease.

Authors:  Ghislaine Prévot; Eliane Bourreau; Herve Pascalis; Roger Pradinaud; Audrey Tanghe; Kris Huygen; Pascal Launois
Journal:  Infect Immun       Date:  2004-02       Impact factor: 3.441

Review 4.  The immunology of other mycobacteria: M. ulcerans, M. leprae.

Authors:  Katharina Röltgen; Gerd Pluschke; John Stewart Spencer; Patrick Joseph Brennan; Charlotte Avanzi
Journal:  Semin Immunopathol       Date:  2020-02-25       Impact factor: 9.623
  4 in total

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