Literature DB >> 10766743

The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression.

E F Hoier1, W A Mohler, S K Kim, A Hajnal.   

Abstract

Inactivation of the Caenorhabditis elegans APC-related gene (apr-1) has pointed at two separate functions of apr-1. First, apr-1 is required for the migration of epithelial cells during morphogenesis of the embryo. In this process, APR-1 may act in a Cadherin/alpha-Catenin/beta-Catenin complex as a component of adherens junctions. Second, apr-1 is required for Hox gene expression, most likely by positively regulating the activity of the Wingless signaling pathway. During embryogenesis, apr-1 is required for the expression of ceh-13 labial in anterior seam and muscle cells and during larval development, apr-1 is necessary for the expression of lin-39 deformed in the vulval precursor cells. Thus, APR-1 may positively regulate the activity of the beta-Catenin/Armadillo-related proteins HMP-2 in migrating epithelial cells and BAR-1 in the vulval precursor cells.

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Year:  2000        PMID： 10766743      PMCID： PMC316495     

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  58 in total

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Journal:  Dev Biol       Date:  1998-12-01       Impact factor: 3.582

Review 2.  Mechanisms of Wnt signaling in development.

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Journal:  Methods Cell Biol       Date:  1995       Impact factor: 1.441

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Journal:  Dev Biol       Date:  1994-02       Impact factor: 3.582

Review 5.  Homeobox genes: their function in Drosophila segmentation and pattern formation.

Authors:  P A Lawrence; G Morata
Journal:  Cell       Date:  1994-07-29       Impact factor: 41.582

6.  A homeotic gene cluster patterns the anteroposterior body axis of C. elegans.

Authors:  B B Wang; M M Müller-Immergluck; J Austin; N T Robinson; A Chisholm; C Kenyon
Journal:  Cell       Date:  1993-07-16       Impact factor: 41.582

7.  Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.

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Journal:  Science       Date:  1997-03-21       Impact factor: 47.728

8.  Apoptosis and APC in colorectal tumorigenesis.

Authors:  P J Morin; B Vogelstein; K W Kinzler
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205

9.  The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

Authors:  I S Näthke; C L Adams; P Polakis; J H Sellin; W J Nelson
Journal:  J Cell Biol       Date:  1996-07       Impact factor: 10.539

10.  Muscle organization in Caenorhabditis elegans: localization of proteins implicated in thin filament attachment and I-band organization.

Authors:  G R Francis; R H Waterston
Journal:  J Cell Biol       Date:  1985-10       Impact factor: 10.539
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  35 in total

Review 1.  The early bird catches the worm: new technologies for the Caenorhabditis elegans toolkit.

Authors:  Xiao Xu; Stuart K Kim
Journal:  Nat Rev Genet       Date:  2011-10-04       Impact factor: 53.242

2.  Developmental expression of FOG-1/CPEB protein and its control in the Caenorhabditis elegans hermaphrodite germ line.

Authors:  Liana B Lamont; Judith Kimble
Journal:  Dev Dyn       Date:  2007-03       Impact factor: 3.780

Review 3.  Non-neuronal cell outgrowth in C. elegans.

Authors:  Srimoyee Ghosh; Sylvia A Vetrone; Paul W Sternberg
Journal:  Worm       Date:  2017-11-14

4.  The CRAL/TRIO and GOLD domain protein CGR-1 promotes induction of vulval cell fates in Caenorhabditis elegans and interacts genetically with the Ras signaling pathway.

Authors:  Jessica L Goldstein; Danielle Glossip; Sudhir Nayak; Kerry Kornfeld
Journal:  Genetics       Date:  2005-10-11       Impact factor: 4.562

Review 5.  Recent advances in functional genomics for parasitic nematodes of mammals.

Authors:  Michelle L Castelletto; Spencer S Gang; Elissa A Hallem
Journal:  J Exp Biol       Date:  2020-02-07       Impact factor: 3.312

6.  The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo.

Authors:  L Natarajan; N E Witwer; D M Eisenmann
Journal:  Genetics       Date:  2001-09       Impact factor: 4.562

7.  Cell Non-autonomous Function of daf-18/PTEN in the Somatic Gonad Coordinates Somatic Gonad and Germline Development in C. elegans Dauer Larvae.

Authors:  Claudia C Tenen; Iva Greenwald
Journal:  Curr Biol       Date:  2019-02-28       Impact factor: 10.834

8.  RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.

Authors:  Ester W Frische; Wendy Pellis-van Berkel; Gijs van Haaften; Edwin Cuppen; Ronald H A Plasterk; Marcel Tijsterman; Johannes L Bos; Fried J T Zwartkruis
Journal:  EMBO J       Date:  2007-11-08       Impact factor: 11.598

9.  The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development.

Authors:  Zhe Chen; Dennis J Eastburn; Min Han
Journal:  Mol Cell Biol       Date:  2004-09       Impact factor: 4.272

10.  FLP/FRT and Cre/lox recombination technology in C. elegans.

Authors:  E Jane Albert Hubbard
Journal:  Methods       Date:  2014-05-27       Impact factor: 3.608
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