Literature DB >> 10743206

[Mechanism of protective action of Phyllanthus urinaria L. against injuries of liver cells].

S Zhou1, C Xu, N Zhou, Y Huang, L Huang, X Chen, Y Hu, Y Liao.   

Abstract

It has been found out that the carbon tetrachloride (CCl4)-induced increase of serum glutamic-pyruvic transaminase (ALT) and elevation of MDA in liver of mice are significantly lowered by Phyllanthus urinaria in vivo, and the coincubation of isolated rat hepatocytes with Phyllanthus urinaria in vitro significantly inhibits CCl4-induced decrease of mobility of membrane of liver cells and increase of intracellular free Ca2+ ([Ca2+]i) concentrations of liver cells. These results suggest that the anti-lipid peroxidation effect and protective action of membrane of Phyllanthus urinaria may be related to its protective action against CCl4-induced liver injuries.

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Year:  1997        PMID： 10743206

Source DB:  PubMed          Journal:  Zhongguo Zhong Yao Za Zhi        ISSN： 1001-5302


  7 in total

Review 1.  Prevalence and current therapy in chronic liver disorders.

Authors:  Muhammad Daniyal; Muhammad Akram; Rida Zainab; Naveed Munir; Aamir Sharif; Syed Muhammad Ali Shah; Bin Liu; Wei Wang
Journal:  Inflammopharmacology       Date:  2019-02-08       Impact factor: 4.473

2.  Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis.

Authors:  Yin-Quan Tang; Indu Bala Jaganath; Shamala Devi Sekaran
Journal:  PLoS One       Date:  2010-09-08       Impact factor: 3.240

3.  Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2.

Authors:  Sau Har Lee; Yin Quan Tang; Anusyah Rathkrishnan; Seok Mui Wang; Kien Chai Ong; Rishya Manikam; Bobby Joe Payne; Indu Bala Jaganath; Shamala Devi Sekaran
Journal:  BMC Complement Altern Med       Date:  2013-07-26       Impact factor: 3.659

4.  Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells.

Authors:  Surendra Kumar Sharma; Sheela Meruga Arogya; Deepak Hiraganahalli Bhaskarmurthy; Amit Agarwal; Chandrasekaran Chinampudar Velusami
Journal:  Pharmacogn Mag       Date:  2011-07       Impact factor: 1.085

5.  A Review of the Phytochemistry and Pharmacology of Phyllanthus urinaria L.

Authors:  Madamanchi Geethangili; Shih-Torng Ding
Journal:  Front Pharmacol       Date:  2018-10-01       Impact factor: 5.810

6.  Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles.

Authors:  Hua-Yew Cheng; Chien-Min Yang; Ta-Chen Lin; Liang-Tzung Lin; Lien-Chai Chiang; Chun-Ching Lin
Journal:  Evid Based Complement Alternat Med       Date:  2011-05-26       Impact factor: 2.629

7.  A Complex Multiherbal Regimen Based on Ayurveda Medicine for the Management of Hepatic Cirrhosis Complicated by Ascites: Nonrandomized, Uncontrolled, Single Group, Open-Label Observational Clinical Study.

Authors:  Manish V Patel; Kalapi B Patel; Shivenarain Gupta; Andreas Michalsen; Elmar Stapelfeldt; Christian S Kessler
Journal:  Evid Based Complement Alternat Med       Date:  2015-08-03       Impact factor: 2.629
  7 in total

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