PURPOSE: To test the hypothesis that magnetic resonance (MR) imaging can guide the percutaneous treatment of renal artery stenosis in a pig model. MATERIALS AND METHODS: Ameroid constrictors were surgically placed around six renal arteries in four pigs. After 30-36 days, all stenoses were documented by conventional x-ray aortograms. MR-guided renal angioplasty was attempted for three stenoses. For these pigs, MR angiography was performed with use of contrast-enhanced three-dimensional (3D) techniques. The authors visualized catheters by filling them with dilute 4% gadolinium and imaging with two-dimensional (2D) and 3D MR fast spoiled gradient recalled echo techniques. Under MR guidance, the authors advanced a selective catheter into the affected renal artery and crossed the stenosis with a nitinol guide wire. Angioplasty was performed with a balloon catheter filled with dilute gadolinium. Stenosis and luminal diameter measurements were compared before and after angioplasty. RESULTS: After ameroid constrictor placement, four significant stenoses, one mild stenosis, and one occlusion developed. Under MR guidance, the authors achieved technical success in performing three of three (100%) attempted dilations. After MR-guided angioplasty, the mean reduction in stenosis was 35% and the mean increase in luminal diameter was 1.6 mm. CONCLUSION: Use of MR guidance for the angioplasty of renal artery stenosis in pigs is feasible.
PURPOSE: To test the hypothesis that magnetic resonance (MR) imaging can guide the percutaneous treatment of renal artery stenosis in a pig model. MATERIALS AND METHODS: Ameroid constrictors were surgically placed around six renal arteries in four pigs. After 30-36 days, all stenoses were documented by conventional x-ray aortograms. MR-guided renal angioplasty was attempted for three stenoses. For these pigs, MR angiography was performed with use of contrast-enhanced three-dimensional (3D) techniques. The authors visualized catheters by filling them with dilute 4% gadolinium and imaging with two-dimensional (2D) and 3D MR fast spoiled gradient recalled echo techniques. Under MR guidance, the authors advanced a selective catheter into the affected renal artery and crossed the stenosis with a nitinol guide wire. Angioplasty was performed with a balloon catheter filled with dilute gadolinium. Stenosis and luminal diameter measurements were compared before and after angioplasty. RESULTS: After ameroid constrictor placement, four significant stenoses, one mild stenosis, and one occlusion developed. Under MR guidance, the authors achieved technical success in performing three of three (100%) attempted dilations. After MR-guided angioplasty, the mean reduction in stenosis was 35% and the mean increase in luminal diameter was 1.6 mm. CONCLUSION: Use of MR guidance for the angioplasty of renal artery stenosis in pigs is feasible.
Authors: Robert J Lederman; Michael A Guttman; Dana C Peters; Richard B Thompson; Jonathan M Sorger; Alexander J Dick; Venkatesh K Raman; Elliot R McVeigh Journal: Circulation Date: 2002-03-19 Impact factor: 29.690
Authors: Jordin D Green; Reed A Omary; Brian E Schirf; Richard Tang; Biao Lu; James A Gehl; J Jenny Huang; James C Carr; F Scott Pereles; Debiao Li Journal: Magn Reson Med Date: 2005-11 Impact factor: 4.668
Authors: Amish N Raval; Parag V Karmarkar; Michael A Guttman; Cengizhan Ozturk; Ranil Desilva; Ronnier J Aviles; Victor J Wright; William H Schenke; Ergin Atalar; Elliot R McVeigh; Robert J Lederman Journal: Catheter Cardiovasc Interv Date: 2006-04 Impact factor: 2.692
Authors: Amish N Raval; James D Telep; Michael A Guttman; Cengizhan Ozturk; Michael Jones; Richard B Thompson; Victor J Wright; William H Schenke; Ranil DeSilva; Ronnier J Aviles; Venkatesh K Raman; Michael C Slack; Robert J Lederman Journal: Circulation Date: 2005-07-25 Impact factor: 29.690