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Literature DB >> 8394002

"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.

S H DeWitt¹, J S Kiely, C J Stankovic, M C Schroeder, D M Cody, M R Pavia.

Abstract

Solid-phase chemistry, organic synthesis, and an apparatus for multiple, simultaneous synthesis have been combined to generate libraries of organic compounds ("diversomers"). Arrays of compounds were synthesized over two to three steps incorporating chemically diverse building blocks on a polystyrene-based solid support in a multiple, simultaneous manner. The generality of this approach is illustrated by the syntheses of dipeptides, hydantoins, and benzodiazepines.

Entities: Chemical

Mesh：

Substances：

Year: 1993 PMID： 8394002 PMCID： PMC47044 DOI： 10.1073/pnas.90.15.6909

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

9 in total

1. Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis.

Authors: R N Zuckermann; J M Kerr; M A Siani; S C Banville; D V Santi
Journal: Proc Natl Acad Sci U S A Date: 1992-05-15 Impact factor: 11.205

2. Searching for peptide ligands with an epitope library.

Authors: J K Scott; G P Smith
Journal: Science Date: 1990-07-27 Impact factor: 47.728

3. Light-directed, spatially addressable parallel chemical synthesis.

Authors: S P Fodor; J L Read; M C Pirrung; L Stryer; A T Lu; D Solas
Journal: Science Date: 1991-02-15 Impact factor: 47.728

4. Random peptide libraries: a source of specific protein binding molecules.

Authors: J J Devlin; L C Panganiban; P E Devlin
Journal: Science Date: 1990-07-27 Impact factor: 47.728

5. Examination of the secondary structure of proteins by deconvolved FTIR spectra.

Authors: D M Byler; H Susi
Journal: Biopolymers Date: 1986-03 Impact factor: 2.505

6. Peptides on phage: a vast library of peptides for identifying ligands.

Authors: S E Cwirla; E A Peters; R W Barrett; W J Dower
Journal: Proc Natl Acad Sci U S A Date: 1990-08 Impact factor: 11.205

7. 1-Azacycloalkyl-1,4-benzodiazepin-2-ones with antianxiety-antidepressant actions.

Authors: T Sugasawa; M Adachi; K Sasakura; A Matsushita; M Eigyo; T Shiomi; H Shintaku; Y Takahara; S Murata
Journal: J Med Chem Date: 1985-06 Impact factor: 7.446

8. p-alkoxybenzyl alcohol resin and p-alkoxybenzyloxycarbonylhydrazide resin for solid phase synthesis of protected peptide fragments.

Authors: S S Wang
Journal: J Am Chem Soc Date: 1973-02-21 Impact factor: 15.419

9. Peptoids: a modular approach to drug discovery.

Authors: R J Simon; R S Kania; R N Zuckermann; V D Huebner; D A Jewell; S Banville; S Ng; L Wang; S Rosenberg; C K Marlowe
Journal: Proc Natl Acad Sci U S A Date: 1992-10-15 Impact factor: 11.205

9 in total

29 in total

"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.

1. Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis.

2. Searching for peptide ligands with an epitope library.

3. Light-directed, spatially addressable parallel chemical synthesis.

4. Random peptide libraries: a source of specific protein binding molecules.

5. Examination of the secondary structure of proteins by deconvolved FTIR spectra.

6. Peptides on phage: a vast library of peptides for identifying ligands.

7. 1-Azacycloalkyl-1,4-benzodiazepin-2-ones with antianxiety-antidepressant actions.

8. p-alkoxybenzyl alcohol resin and p-alkoxybenzyloxycarbonylhydrazide resin for solid phase synthesis of protected peptide fragments.

9. Peptoids: a modular approach to drug discovery.

1. Solid phase synthesis of hydantoins by thermal cyclization and screening of reaction conditions using APOS 1200.

Review 2. Comprehensive survey of combinatorial libraries with undisclosed biological activity: 1992-1997.

Review 3. Combinatorial chemistry: oh what a decade or two can do.

4. Liquid-phase combinatorial synthesis.

5. Solid-phase synthesis of a library of amphipatic hydantoins. Discovery of new hits for TRPV1 blockade.

Review 6. Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents.

7. The impact of polystyrene resins in solid-phase organic synthesis.

8. Xanthines as a scaffold for molecular diversity.

Review 9. Design, synthesis and use of binary encoded synthetic chemical libraries.

10. Fluorous synthesis of hydantoins and thiohydantoins.