Literature DB >> 10708462

Uncoating kinetics of hepatitis A virus virions and provirions.

N E Bishop1, D A Anderson.   

Abstract

When the growth kinetics of immature hepatitis A virus provirions and mature virions were monitored, distinct eclipse phases were noted for both types of particles. Strikingly, uncoating of virions occurred around 4 h postinfection, while uncoating of provirions occurred predominantly between 8 and 10 h postinfection. It is proposed that the heterogeneous mixture of infectious hepatitis A virus particles (virions and provirions) typically present in inocula is responsible for the normally asynchronous nature of hepatitis A virus uncoating kinetics.

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Year:  2000        PMID： 10708462      PMCID： PMC111846          DOI： 10.1128/jvi.74.7.3423-3426.2000

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

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Authors:  I H Madshus; S Olsnes; K Sandvig
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  9 in total

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