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Literature DB >> 10688897

The structure of a stable intermediate in the A <--> B DNA helix transition.

Abstract

The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.

Entities: Chemical

Mesh：

Substances：
DNA

Year: 2000 PMID： 10688897 PMCID： PMC15749 DOI： 10.1073/pnas.040571197

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

29 in total

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Journal: Methods Enzymol Date: 1992 Impact factor: 1.600

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Authors: M C Wahl; M Sundaralingam
Journal: Biopolymers Date: 1997 Impact factor: 2.505

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Authors: H M Berman
Journal: Biopolymers Date: 1997 Impact factor: 2.505

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Journal: Biopolymers Date: 1973 Impact factor: 2.505

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Authors: N Foloppe; A D MacKerell
Journal: Biophys J Date: 1999-06 Impact factor: 4.033

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Journal: J Mol Biol Date: 1992-08-20 Impact factor: 5.469

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Journal: J Mol Biol Date: 1991-12-05 Impact factor: 5.469

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Authors: D Sprous; M A Young; D L Beveridge
Journal: J Mol Biol Date: 1999-01-29 Impact factor: 5.469

34 in total

1. Local conformational variations observed in B-DNA crystals do not improve base stacking: computational analysis of base stacking in a d(CATGGGCCCATG)(2) B<-->A intermediate crystal structure.

Authors: J Poner; J Florián; H L Ng; J E Poner; N Packová
Journal: Nucleic Acids Res Date: 2000-12-15 Impact factor: 16.971

Review 2. DNA structure from A to B.

Authors: R E Dickerson; H L Ng
Journal: Proc Natl Acad Sci U S A Date: 2001-06-19 Impact factor: 11.205

3. A crystallographic map of the transition from B-DNA to A-DNA.

Authors: J M Vargason; K Henderson; P S Ho
Journal: Proc Natl Acad Sci U S A Date: 2001-06-05 Impact factor: 11.205

4. Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract.

Authors: Pinar Iyidogan; Karen S Anderson
Journal: Antiviral Res Date: 2012-06-01 Impact factor: 5.970