Literature DB >> 10688801

Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript.

G C Perng1, C Jones, J Ciacci-Zanella, M Stone, G Henderson, A Yukht, S M Slanina, F M Hofman, H Ghiasi, A B Nesburn, S L Wechsler.   

Abstract

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT(-) virus but not with LAT(+) viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

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Year:  2000        PMID： 10688801     DOI： 10.1126/science.287.5457.1500

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  216 in total

1.  Enhancer and long-term expression functions of herpes simplex virus type 1 latency-associated promoter are both located in the same region.

Authors:  H Berthomme; J Thomas; P Texier; A Epstein; L T Feldman
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

2.  Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo.

Authors:  Maryam Ahmed; Martin Lock; Cathie G Miller; Nigel W Fraser
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

Review 3.  Herpes simplex virus evolved to use the human defense mechanisms to establish a lifelong infection in neurons--a review and hypothesis.

Authors:  Yechiel Becker
Journal:  Virus Genes       Date:  2002-03       Impact factor: 2.332

4.  The stable 2.0-kilobase intron of the herpes simplex virus type 1 latency-associated transcript does not function as an antisense repressor of ICP0 in nonneuronal cells.

Authors:  Edward A Burton; Chang-Sook Hong; Joseph C Glorioso
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

Review 5.  CD8+ T cells patrol HSV-1-infected trigeminal ganglia and prevent viral reactivation.

Authors:  Anthony J St Leger; Robert L Hendricks
Journal:  J Neurovirol       Date:  2011-12-08       Impact factor: 2.643

6.  Localization of sequences in a protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 that inhibits apoptosis and interferes with Notch1-mediated trans-activation of the bICP0 promoter.

Authors:  Devis Sinani; Clinton Jones
Journal:  J Virol       Date:  2011-09-21       Impact factor: 5.103

Review 7.  Herpes simplex virus latency-associated transcript gene function.

Authors:  Jennifer R Kent; Wen Kang; Cathie G Miller; Nigel W Fraser
Journal:  J Neurovirol       Date:  2003-06       Impact factor: 2.643

8.  Wide variations in herpes simplex virus type 1 inoculum dose and latency-associated transcript expression phenotype do not alter the establishment of latency in the rabbit eye model.

Authors:  J E O'Neil; J M Loutsch; J S Aguilar; J M Hill; E K Wagner; D C Bloom
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

9.  Deletion of Herpes Simplex Virus 1 MicroRNAs miR-H1 and miR-H6 Impairs Reactivation.

Authors:  Enrico R Barrozo; Sanae Nakayama; Pankaj Singh; Emilia A H Vanni; Ann M Arvin; Donna M Neumann; David C Bloom
Journal:  J Virol       Date:  2020-07-16       Impact factor: 5.103

10.  The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.

Authors:  Weiping Peng; Gail Henderson; Guey-Chuen Perng; Anthony B Nesburn; Steven L Wechsler; Clinton Jones
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103
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