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Literature DB >> 1067621

Morphinomimetic activity of synthetic fragments of beta-lipotropin and analogs.

Abstract

In the myenteric plexus-longitudinal muscle bioassay, beta-endorphin, i.e., beta-lipotropin (beta-LPH)-[61-91], has a potency of 450 with confidence limits of 281-966 when Met5-enkephalin is used as a reference standard with a potency of 100. The primary amide and the ethylamide of Met5-enkephalin have potencies statistically overlapping with that of beta-endorphin. The primary amide of alpha-endorphin has twice the potency of the free acid form of alpha-endorphin. An intact NH2-terminal tyrosine is not necessary for full intrinsic activity. The shortest fragment of beta-LPH with morphinomimetic activity is beta-LPH-[61-64].

Entities: Chemical Gene

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Year: 1976 PMID： 1067621 PMCID： PMC431021 DOI： 10.1073/pnas.73.9.3308

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.

Authors: B M Cox; A Goldstein; C H Hi
Journal: Proc Natl Acad Sci U S A Date: 1976-06 Impact factor: 11.205

2. beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.

Authors: L H Lazarus; N Ling; R Guillemin
Journal: Proc Natl Acad Sci U S A Date: 1976-06 Impact factor: 11.205

3. Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.

Authors: C H Li; D Chung
Journal: Proc Natl Acad Sci U S A Date: 1976-04 Impact factor: 11.205

4. Effect of peptides and amino acids on dihydromorphine binding to the opiate receptor.

Authors: L Terenius
Journal: J Pharm Pharmacol Date: 1975-06 Impact factor: 3.765

5. ACTH-like peptides and opiate receptors in the rat brain: structure-activity studies.

Authors: L Terenius; W H Gispen; D De Wied
Journal: Eur J Pharmacol Date: 1975 Sep-Oct Impact factor: 4.432

6. Analogs of luteinizing hormone releasing factor (LRF). Synthesis and biological activity of ((Nalpha-Me)Leu-7)LRF and (D-Ala-6,(Nalpha-Me)Leu-7)LRF.

Authors: N Ling; W Vale
Journal: Biochem Biophys Res Commun Date: 1975-04-07 Impact factor: 3.575

7. [Endorphins, hypothalamic and neurohypophysial peptides with morphinomimetic activity: isolation and molecular structure of alpha-endorphin].

Authors: R Guillemin; N Ling; R Burgus
Journal: C R Acad Hebd Seances Acad Sci D Date: 1976-02-23

Review 8. Interactions of narcotic antagonists with receptor sites.

Authors: A Goldstein
Journal: Adv Biochem Psychopharmacol Date: 1973

9. Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.

Authors: R Simantov; S H Snyder
Journal: Proc Natl Acad Sci U S A Date: 1976-07 Impact factor: 11.205

10. The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips.

Authors: W D Paton; M A Zar
Journal: J Physiol Date: 1968-01 Impact factor: 5.182

15 in total

Review 1. The enkephalins. Peptides with morphine-like activity.

Authors: R J Miller; P Cuatrecasas
Journal: Naturwissenschaften Date: 1978-10

2. Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.

Authors: N Ling; R Burgus; R Guillemin
Journal: Proc Natl Acad Sci U S A Date: 1976-11 Impact factor: 11.205

3. Effects of peptides of pituitary origin on the formation of C21 steroid by fetal calf adrenal cells in culture.

Authors: K W Kan; A Baird; N G Seidah; M Lis; M Chrétien; N Ling; R Guillemin; S Solomon
Journal: Biochem Biophys Res Commun Date: 1977-11-21 Impact factor: 3.575

4. Distribution of ACTH-like immunoreactivity in rat brain and gastrointestinal tract.

Authors: L I Larsson
Journal: Histochemistry Date: 1978-04-04

5. Immunologic localization of alpha- and beta-endorphins and beta-lipotropin in corticotropic cells of the normal and anencephalic fetal pituitaries.

Authors: M Bégeot; M P Dubois; P M Dubois
Journal: Cell Tissue Res Date: 1978-10-30 Impact factor: 5.249