Literature DB >> 1064883

beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.

L H Lazarus, N Ling, R Guillemin.   

Abstract

The hypophysial homomeric peptide beta-lipotropin (beta-LPH-[1-91]) has no morphinomomimetic activity in a bioassay (myenteric plexus-longitudinal muscle of the guinea pig's ileum) or binding assays with stereospecific opiate-receptors of rat brain synaptosome preparations. Incubating beta-LPH-[1-91] at neutral pH with the supernatant aqueous extracts of rat brain generates (fragments of beta-LPH with) morphinomimetic activity in the same assay systems. These results are related to the recently recognized structural relationships between beta-LPH, the newly isolated peptides met-enkephalin (beta-LPH-[61-65]) and alpha-endorphin (beta-LPH-[61-76]) and also to the biologically active fragments of analogs: beta-LPH-[61-64], beta-LPH-[61-65[-NH2, (Met(O)65)-BETA-LPH-[61-65], beta-LPH-[61-69], and beta-LPH-[61-69]. Enzymatic biogenesis of these morphinomimetic peptides would preclude localizing them as such in cellular or subcellular elements with currently available methodology.

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Year:  1976        PMID： 1064883      PMCID： PMC430469          DOI： 10.1073/pnas.73.6.2156

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  LIPOTROPIN, A NEW ACTIVE PEPTIDE FROM PITUITARY GLANDS.

Authors:  C H LI
Journal:  Nature       Date:  1964-02-29       Impact factor: 49.962

Review 2.  THE RENIN-ANGIOTENSIN SYSTEM.

Authors:  W S PEART
Journal:  Pharmacol Rev       Date:  1965-06       Impact factor: 25.468

3.  Angiotensin-converting enzyme in human brain.

Authors:  M M Poth; R G Heath; M Ward
Journal:  J Neurochem       Date:  1975-07       Impact factor: 5.372

4.  Angiotensin-forming enzyme in human brain.

Authors:  C B Daul; R G Heath; R E Garey
Journal:  Neuropharmacology       Date:  1975-01       Impact factor: 5.250

5.  Narcotic receptor sites in morphine-dependent rats.

Authors:  W A Klee; R A Streaty
Journal:  Nature       Date:  1974-03-01       Impact factor: 49.962

6.  Biological proprtie of ovine beta-lipotropic hormone.

Authors:  P Lohmar; C H Li
Journal:  Endocrinology       Date:  1968-05       Impact factor: 4.736

7.  On a possible role of beta-melanocyte stimulating hormone (beta-MSH) in the central nervous system of the Mammalia: enzymatic inactivation in vitro of beta-MSH by brain tissue.

Authors:  J M LONG; W A KRIVOY; R GUILLEMIN
Journal:  Endocrinology       Date:  1961-07       Impact factor: 4.736

8.  Renin activity in dog brain: enzymological similarity to cathepsin D.

Authors:  R P Day; I A Reid
Journal:  Endocrinology       Date:  1976-07       Impact factor: 4.736

9.  The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips.

Authors:  W D Paton; M A Zar
Journal:  J Physiol       Date:  1968-01       Impact factor: 5.182

10.  Adrenocorticotrophic and melanocyte-stimulating peptides in the human pituitary.

Authors:  A P Scott; P J Lowry
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857
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  33 in total

1.  The sheep pars tuberalis: an immunohistochemical study. Demonstration of the presence of glycoprotein and lipotropin hormones.

Authors:  Y Tillet; J Pelletier; G Tramu; M M de Reviers
Journal:  Histochemistry       Date:  1990

2.  Tolerance and dependence evoked by an endogenous opiate peptide.

Authors:  A Lampert; M Nirenberg; W A Klee
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205

3.  Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.

Authors:  N Ling; R Burgus; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

4.  Biomarker discovery and clinical proteomics.

Authors:  Jerzy Silberring; Pawel Ciborowski
Journal:  Trends Analyt Chem       Date:  2010-02-01       Impact factor: 12.296

5.  Endogenous ligands of opiate receptors.

Authors:  H Teschemacher
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977       Impact factor: 3.000

6.  Human beta-endorphin: the real opium of the people?

Authors: 
Journal:  Br Med J       Date:  1978-07-15

7.  beta-Lipotropin is the major opioid-like peptide of human pituitary and rat pars distalis: lack of significant beta-endorphin.

Authors:  A S Liotta; T Suda; D T Krieger
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

8.  Psychopharmacological and endocrinological effects of melanocyte stimulating hormones in normal man.

Authors:  H Ashton; J E Millman; R Telford; J W Thompson; T F Davies; R Hall; S Shuster; A J Thody; D H Coy; A J Kastin
Journal:  Psychopharmacology (Berl)       Date:  1977-12-19       Impact factor: 4.530

9.  The nature of the immunoreactive lipotropins in human plasma and tissue extracts.

Authors:  K Tanaka; W E Nicholson; D N Orth
Journal:  J Clin Invest       Date:  1978-07       Impact factor: 14.808

10.  Ontogenesis of cells producing polypeptide hormones (ACTH, MSH, LPH, GH, prolactin) in the fetal hypophysis of the rat: influence of the hypothalamus.

Authors:  A Chatelain; J P Dupouy; M P Dubois
Journal:  Cell Tissue Res       Date:  1979-02-28       Impact factor: 5.249
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