BACKGROUND: Arterial remodeling in response to atherosclerosis may be outward (positive) or inward (negative) and is an important mechanism in the clinical manifestations of atherosclerosis and restenosis after percutaneous coronary interventions. Postmortem and intravascular ultrasound studies of arterial remodeling do not allow serial and noninvasive data to be obtained. In a rabbit model of atherosclerosis, we sought to validate MRI as a new tool for documentation of arterial remodeling. METHODS AND RESULTS: Watanabe heritable hyperlipidemic rabbits underwent serial MRI at baseline and 6 months after aortic balloon denudation. The lumen area had a small but significant (P=0.006) increase, from 4.36+/-0.16 to 4. 89+/-0.12 mm(2). There was a large, significant (P<0.0001) increase in the outer wall area, from 7.96+/-0.19 to 10.46+/-0.19 mm(2). The vessel wall area (a marker of atherosclerotic burden) increased significantly (P<0.0001), from 3.61+/-0.07 to 5.57+/-0.09 mm(2). Thus, the increase in atherosclerotic burden over time was completely accounted for by positive arterial remodeling. The subgroup used for histopathological validation confirmed a significant (P<0.0001) agreement between histopathology and MRI for assessment of all 3 parameters. CONCLUSIONS: MRI can provide serial and noninvasive data about the arterial wall, allowing assessment of arterial remodeling in this rabbit model. Thus, MRI appears to be a useful tool for the investigation of arterial remodeling both in native atherosclerosis and after percutaneous coronary intervention.
BACKGROUND: Arterial remodeling in response to atherosclerosis may be outward (positive) or inward (negative) and is an important mechanism in the clinical manifestations of atherosclerosis and restenosis after percutaneous coronary interventions. Postmortem and intravascular ultrasound studies of arterial remodeling do not allow serial and noninvasive data to be obtained. In a rabbit model of atherosclerosis, we sought to validate MRI as a new tool for documentation of arterial remodeling. METHODS AND RESULTS: Watanabe heritable hyperlipidemic rabbits underwent serial MRI at baseline and 6 months after aortic balloon denudation. The lumen area had a small but significant (P=0.006) increase, from 4.36+/-0.16 to 4. 89+/-0.12 mm(2). There was a large, significant (P<0.0001) increase in the outer wall area, from 7.96+/-0.19 to 10.46+/-0.19 mm(2). The vessel wall area (a marker of atherosclerotic burden) increased significantly (P<0.0001), from 3.61+/-0.07 to 5.57+/-0.09 mm(2). Thus, the increase in atherosclerotic burden over time was completely accounted for by positive arterial remodeling. The subgroup used for histopathological validation confirmed a significant (P<0.0001) agreement between histopathology and MRI for assessment of all 3 parameters. CONCLUSIONS: MRI can provide serial and noninvasive data about the arterial wall, allowing assessment of arterial remodeling in this rabbit model. Thus, MRI appears to be a useful tool for the investigation of arterial remodeling both in native atherosclerosis and after percutaneous coronary intervention.
Authors: Filippo Cademartiri; Nico R Mollet; Giuseppe Runza; Nico Bruining; Ronald Hamers; Pamela Somers; Michiel Knaapen; Stefan Verheye; Massimo Midiri; Gabriel P Krestin; Pim J de Feyter Journal: Eur Radiol Date: 2005-03-05 Impact factor: 5.315
Authors: M T Johnstone; R M Botnar; A S Perez; R Stewart; W C Quist; J A Hamilton; W J Manning Journal: Arterioscler Thromb Vasc Biol Date: 2001-09 Impact factor: 8.311
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Authors: Laszlo Hegyi; Paul D Hockings; Martin G Benson; Albert L Busza; Philip Overend; David C Grimsditch; Katherine J Burton; Heather Lloyd; Greg A Whelan; Jeremy N Skepper; Martin P Vidgeon-Hart; Adrian T Carpenter; David G Reid; Keith E Suckling; Peter L Weissberg Journal: Pathol Oncol Res Date: 2004-09-25 Impact factor: 3.201
Authors: M Wintermark; S S Jawadi; J H Rapp; T Tihan; E Tong; D V Glidden; S Abedin; S Schaeffer; G Acevedo-Bolton; B Boudignon; B Orwoll; X Pan; D Saloner Journal: AJNR Am J Neuroradiol Date: 2008-02-13 Impact factor: 3.825
Authors: Cuilian Miao; Shaoguang Chen; Robson Macedo; Shenghan Lai; Kiang Liu; Debiao Li; Bruce A Wasserman; Jens Vogel-Claussen; Jens Vogel-Clausen; João A C Lima; David A Bluemke Journal: J Am Coll Cardiol Date: 2009-05-05 Impact factor: 24.094