BACKGROUND: Occult primary breast cancer (OPBC) represents less than 1% of breast cancer. In only a third of cases, mammography identifies a primary tumor. We hypothesized that rotating delivery of excitation off-resonance breast magnetic resonance imaging (MRI) would identify or exclude the breast as a primary site in patients with OPBC. METHODS: In a retrospective review, 10 patients were identified with OPBC in which MRI was performed. Malignant appearing lesions were correlated with histopathologic findings at biopsy or surgery. RESULTS: MRI identified the primary site in 8 of 10 cases as breast (80%), and excluded it in 2 cases. The extent of disease and location was accurately predicted when compared with histopathologic specimen. CONCLUSIONS: As we continue to focus on a cure of early breast cancer, it is imperative that diagnostic images become more sensitive and specific. MRI accurately predicted OPBC in this subset of patients.
BACKGROUND:Occult primary breast cancer (OPBC) represents less than 1% of breast cancer. In only a third of cases, mammography identifies a primary tumor. We hypothesized that rotating delivery of excitation off-resonance breast magnetic resonance imaging (MRI) would identify or exclude the breast as a primary site in patients with OPBC. METHODS: In a retrospective review, 10 patients were identified with OPBC in which MRI was performed. Malignant appearing lesions were correlated with histopathologic findings at biopsy or surgery. RESULTS: MRI identified the primary site in 8 of 10 cases as breast (80%), and excluded it in 2 cases. The extent of disease and location was accurately predicted when compared with histopathologic specimen. CONCLUSIONS: As we continue to focus on a cure of early breast cancer, it is imperative that diagnostic images become more sensitive and specific. MRI accurately predicted OPBC in this subset of patients.
Authors: Oluwadamilola M Fayanju; Carolyn R T Stoll; Susan Fowler; Graham A Colditz; Donna B Jeffe; Julie A Margenthaler Journal: Ann Surg Oncol Date: 2013-08-22 Impact factor: 5.344
Authors: Wendy B DeMartini; Laura Ichikawa; Bonnie C Yankaskas; Diana Buist; Karla Kerlikowske; Berta Geller; Tracy Onega; Robert D Rosenberg; Constance D Lehman Journal: J Am Coll Radiol Date: 2010-11 Impact factor: 5.532
Authors: Wendy B Demartini; Brenda F Kurland; Robert L Gutierrez; C Craig Blackmore; Sue Peacock; Constance D Lehman Journal: Eur Radiol Date: 2011-02-27 Impact factor: 5.315
Authors: C Walter; K Scheidhauer; A Scharl; U-J Goering; P Theissen; H Kugel; T Krahe; U Pietrzyk Journal: Eur Radiol Date: 2003-01-23 Impact factor: 5.315
Authors: Wendy B DeMartini; Lucy Hanna; Constantine Gatsonis; Mary C Mahoney; Constance D Lehman Journal: AJR Am J Roentgenol Date: 2012-09 Impact factor: 3.959
Authors: Katrien Schelfout; E Kersschot; M Van Goethem; L Thienpont; J Van den Haute; A Roelstraete; A De Schepper Journal: Eur Radiol Date: 2002-11-19 Impact factor: 5.315