Literature DB >> 10668169

Synthesis, binding affinity and selectivity of new beta 1- and beta 2-adrenoceptor blockers.

V Brizzi1, M Francioli, M Brufani, L Filocamo, G Bruni, P Massarelli.   

Abstract

The synthesis of a new series of sesamol derivatives with beta-adrenergic blocking activity is described. The affinity and selectivity of these compounds for beta 1- and beta 2-adrenoceptors were studied in comparison with those of ICI-118551 and propranolol. Some of the synthesized compounds show very good affinity for the beta 2-receptors of rat lung membranes and two of them provide interesting selectivity.

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Year:  1999        PMID： 10668169     DOI： 10.1016/s0014-827x(99)00077-4

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  2 in total

1.  Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation.

Authors:  Amit Gupta; Rajendra Singh; Pankaj K Sonar; Shailendra K Saraf
Journal:  Biochem Res Int       Date:  2016-01-26

2.  A novel synthesis, X-ray analysis and computational studies of (Z)-ethyl 2-((Z)-5-((dimethylamino)methylene)- 4-oxo-3-phenylthiazolidin-2-ylidene)acetate as a potential anticancer agent.

Authors:  Yahia N Mabkhot; Mohammed M Alharbi; Salim S Al-Showiman; Saied M Soliman; Nabila A Kheder; Wolfgang Frey; Abdulrhman Asayari; Abdullatif Bin Muhsinah; H Algarni
Journal:  BMC Chem       Date:  2019-03-26
  2 in total

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