OBJECTIVES: To describe the clinical manifestations of viral hemorrhagic fever, and to increase clinicians' awareness and knowledge of these illnesses. DESIGN: Retrospective study of the clinical and laboratory data and management of two cases of Ebola virus infection with key epidemiologic data provided. SETTING: Two tertiary care hospitals. PATIENTS: Two adult patients, the index case and the source patient, both identified as having Ebola, one of whom originated in Gabon. INTERVENTIONS: One patient was admitted to the intensive care unit. The other was managed in a general ward. MEASUREMENT AND MAIN RESULTS: Clinical and laboratory data are reported. One patient, a healthcare worker who contracted this illness in the course of her work, died of refractory thrombocytopenia and an intracerebral bleed. The source patient survived. Despite a long period during which the diagnosis was obscure, none of the other 300 contacts contracted the illness. CONCLUSIONS: Identification of high-risk patients and use of universal blood and body fluid precautions will considerably decrease the risk of nosocomial spread of viral hemorrhagic fevers.
OBJECTIVES: To describe the clinical manifestations of viral hemorrhagic fever, and to increase clinicians' awareness and knowledge of these illnesses. DESIGN: Retrospective study of the clinical and laboratory data and management of two cases of Ebola virus infection with key epidemiologic data provided. SETTING: Two tertiary care hospitals. PATIENTS: Two adult patients, the index case and the source patient, both identified as having Ebola, one of whom originated in Gabon. INTERVENTIONS: One patient was admitted to the intensive care unit. The other was managed in a general ward. MEASUREMENT AND MAIN RESULTS: Clinical and laboratory data are reported. One patient, a healthcare worker who contracted this illness in the course of her work, died of refractory thrombocytopenia and an intracerebral bleed. The source patient survived. Despite a long period during which the diagnosis was obscure, none of the other 300 contacts contracted the illness. CONCLUSIONS: Identification of high-risk patients and use of universal blood and body fluid precautions will considerably decrease the risk of nosocomial spread of viral hemorrhagic fevers.
Authors: Suzanne E Mate; Jeffrey R Kugelman; Tolbert G Nyenswah; Jason T Ladner; Michael R Wiley; Thierry Cordier-Lassalle; Athalia Christie; Gary P Schroth; Stephen M Gross; Gloria J Davies-Wayne; Shivam A Shinde; Ratnesh Murugan; Sonpon B Sieh; Moses Badio; Lawrence Fakoli; Fahn Taweh; Emmie de Wit; Neeltje van Doremalen; Vincent J Munster; James Pettitt; Karla Prieto; Ben W Humrighouse; Ute Ströher; Joseph W DiClaro; Lisa E Hensley; Randal J Schoepp; David Safronetz; Joseph Fair; Jens H Kuhn; David J Blackley; A Scott Laney; Desmond E Williams; Terrence Lo; Alex Gasasira; Stuart T Nichol; Pierre Formenty; Francis N Kateh; Kevin M De Cock; Fatorma Bolay; Mariano Sanchez-Lockhart; Gustavo Palacios Journal: N Engl J Med Date: 2015-10-14 Impact factor: 91.245
Authors: Anita K McElroy; Bobbie R Erickson; Timothy D Flietstra; Pierre E Rollin; Jonathan S Towner; Stuart T Nichol; Christina F Spiropoulou Journal: Viral Immunol Date: 2015-02 Impact factor: 2.257
Authors: Pauline Vetter; William A Fischer; Manuel Schibler; Michael Jacobs; Daniel G Bausch; Laurent Kaiser Journal: J Infect Dis Date: 2016-07-20 Impact factor: 5.226
Authors: François Lamontagne; Robert A Fowler; Neill K Adhikari; Srinivas Murthy; David M Brett-Major; Michael Jacobs; Timothy M Uyeki; Constanza Vallenas; Susan L Norris; William A Fischer; Thomas E Fletcher; Adam C Levine; Paul Reed; Daniel G Bausch; Sandy Gove; Andrew Hall; Susan Shepherd; Reed A Siemieniuk; Marie-Claude Lamah; Rashida Kamara; Phiona Nakyeyune; Moses J Soka; Ama Edwin; Afeez A Hazzan; Shevin T Jacob; Mubarak Mustafa Elkarsany; Takuya Adachi; Lynda Benhadj; Christophe Clément; Ian Crozier; Armando Garcia; Steven J Hoffman; Gordon H Guyatt Journal: Lancet Date: 2017-10-17 Impact factor: 79.321