| Literature DB >> 29054555 |
François Lamontagne1, Robert A Fowler2, Neill K Adhikari2, Srinivas Murthy3, David M Brett-Major4, Michael Jacobs5, Timothy M Uyeki6, Constanza Vallenas7, Susan L Norris7, William A Fischer8, Thomas E Fletcher9, Adam C Levine10, Paul Reed11, Daniel G Bausch12, Sandy Gove13, Andrew Hall14, Susan Shepherd15, Reed A Siemieniuk16, Marie-Claude Lamah17, Rashida Kamara18, Phiona Nakyeyune19, Moses J Soka20, Ama Edwin21, Afeez A Hazzan22, Shevin T Jacob23, Mubarak Mustafa Elkarsany24, Takuya Adachi25, Lynda Benhadj26, Christophe Clément27, Ian Crozier28, Armando Garcia29, Steven J Hoffman30, Gordon H Guyatt31.
Abstract
The 2013-16 Ebola virus disease outbreak in west Africa was associated with unprecedented challenges in the provision of care to patients with Ebola virus disease, including absence of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care, and limitations in the provision of supportive medical care. Case fatality rates in west Africa were initially greater than 70%, but decreased with improvements in supportive care. To inform optimal care in a future outbreak of Ebola virus disease, we employed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to develop evidence-based guidelines for the delivery of supportive care to patients admitted to Ebola treatment units. Key recommendations include administration of oral and, as necessary, intravenous hydration; systematic monitoring of vital signs and volume status; availability of key biochemical testing; adequate staffing ratios; and availability of analgesics, including opioids, for pain relief.Entities:
Mesh：
Year: 2017 PMID： 29054555 PMCID： PMC6636325 DOI： 10.1016/S0140-6736(17)31795-6
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321