Literature DB >> 1066700

Experimental myasthenia in Balb/c mice immunized with rat acetylcholine receptor from rat denervated muscle.

D A Granato, B W Fulpius, J F Moody.   

Abstract

A new model of an autoimmune disease of the neuromuscular junction was obtained by injection of acetylcholine receptor purified from rat denervated muscles into Balb/c mice. Anti-rat, then anti-mouse acetylcholine receptor antibodies, appear in mouse serum during the immunization procedure. Electrophysiological investigations performed on immunized mice reveal a neuromuscular block similar to that found in myasthenia gravis. Not a single mouse with objective signs of muscular weakness was lacking anti-mouse acetylcholine receptor antibodies but no correlation was found between their level and the severity of the disease.

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Year:  1976        PMID： 1066700      PMCID： PMC430782          DOI： 10.1073/pnas.73.8.2872

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Chromatographic separation of the venom of Bungarus multicinctus and characterization of its components.

Authors:  C Y Lee; S L Chang; S T Kau; S H Luh
Journal:  J Chromatogr       Date:  1972-10-05

2.  Acetylcholine receptor in normal and denervated slow and fast muscle.

Authors:  R R Almon; C G Andrew; S H Appel
Journal:  Biochemistry       Date:  1974-12-31       Impact factor: 3.162

3.  Studies on purified eel acetylcholine receptor and anti-acetylcholine receptor antibody.

Authors:  J Patrick; J Lindstrom; B Culp; J McMillan
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

4.  The acetylcholine receptor. I. Purification and characterization of a macromolecule isolated from Electrophorus electricus.

Authors:  R P Klett; B W Fulpius; D Cooper; M Smith; E Reich; L D Possani
Journal:  J Biol Chem       Date:  1973-10-10       Impact factor: 5.157

5.  Autoimmune response to acetylcholine receptor.

Authors:  J Patrick; J Lindstrom
Journal:  Science       Date:  1973-05-25       Impact factor: 47.728

6.  Immunological studies of acetylcholine receptors.

Authors:  J Lindstrom
Journal:  J Supramol Struct       Date:  1976

7.  The nicotinic cholinergic receptor protein: improved purification method, preliminary amino acid composition and observed auto-immuno response.

Authors:  E Heilbronn; C Mattson
Journal:  J Neurochem       Date:  1974-02       Impact factor: 5.372

8.  Immunological characterisation of the cholinergic receptor protein from Electrophorus electricus.

Authors:  H Sugiyama; P Benda; J C Meunier; J P Changeux
Journal:  FEBS Lett       Date:  1973-09-01       Impact factor: 4.124

9.  Preparation and immunochemical characterization of a water-soluble acetylcholine receptor fraction from the electric organ tissue of the electric eel.

Authors:  A Aharonov; N Kalderon; I Silman; S Fuchs
Journal:  Immunochemistry       Date:  1975-09

10.  Acetylcholine receptor turnover in membranes of developing muscle fibers.

Authors:  P N Devreotes; D M Fambrough
Journal:  J Cell Biol       Date:  1975-05       Impact factor: 10.539
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  11 in total

1.  Myasthenia gravis: further electrophysiological and ultrastructural analysis of transmission failure in the mouse passive transfer model.

Authors:  K V Toyka; K L Birnberger; A P Anzil; C Schlegel; U Besinger; A Struppler
Journal:  J Neurol Neurosurg Psychiatry       Date:  1978-08       Impact factor: 10.154

2.  Experimental autoimmune myasthenia gravis.

Authors:  J Lindstrom
Journal:  J Neurol Neurosurg Psychiatry       Date:  1980-07       Impact factor: 10.154

3.  Induction of the morphologic changes of both acute and chronic experimental myasthenia by monoclonal antibody directed against acetylcholine receptor.

Authors:  C M Gomez; R L Wollmann; D P Richman
Journal:  Acta Neuropathol       Date:  1984       Impact factor: 17.088

4.  Myasthenia gravis. CD4+ T epitopes on the embryonic gamma subunit of human muscle acetylcholine receptor.

Authors:  M P Protti; A A Manfredi; X D Wu; L Moiola; M W Dalton; J F Howard; B M Conti-Tronconi
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

5.  Antibodies from patients with myasthenia gravis recognize determinants unique to extrajunctional acetylcholine receptors.

Authors:  C B Weinberg; Z W Hall
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

6.  Anti-acetylcholine receptor antibodies induced in mice by syngeneic receptor without adjuvants.

Authors:  G K Scadding; L Calder; A Vincent; C Prior; D Wray; J Newsom-Davis
Journal:  Immunology       Date:  1986-05       Impact factor: 7.397

7.  Residues within the alpha subunit sequence 304-322 of muscle acetylcholine receptor forming autoimmune CD4+ epitopes in BALB/c mice.

Authors:  P I Karachunski; N Ostlie; B M Conti-Tronconi; M Bellone
Journal:  Immunology       Date:  1994-05       Impact factor: 7.397

8.  Epitopes on the beta subunit of human muscle acetylcholine receptor recognized by CD4+ cells of myasthenia gravis patients and healthy subjects.

Authors:  L Moiola; P Karachunski; M P Protti; J F Howard; B M Conti-Tronconi
Journal:  J Clin Invest       Date:  1994-03       Impact factor: 14.808

9.  Properties of end-plate channels in rats immunized against acetylcholine receptors.

Authors:  S Alemà; S G Cull-Candy; R Miledi; A Trautmann
Journal:  J Physiol       Date:  1981-02       Impact factor: 5.182

10.  Experimental models of myasthenia gravis: lessons in autoimmunity and progress toward better forms of treatment.

Authors:  A R Pachner
Journal:  Yale J Biol Med       Date:  1987 Mar-Apr
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