| Literature DB >> 10652269 |
A M Reimold1, A Etkin, I Clauss, A Perkins, D S Friend, J Zhang, H F Horton, A Scott, S H Orkin, M C Byrne, M J Grusby, L H Glimcher.
Abstract
XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in death from anemia. Nevertheless, XBP-1-deficient hematopoietic progenitors had no cell-autonomous defect in differentiation. Rather, hepatocyte development itself was severely impaired by two measures: diminished growth rate and prominent apoptosis. Specific target genes of XBP-1 in the liver were identified as alphaFP, which may be a regulator of hepatocyte growth, and three acute phase protein family members. Therefore, XBP-1 is a transcription factor essential for hepatocyte growth.Entities:
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Year: 2000 PMID： 10652269 PMCID： PMC316338
Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361