Literature DB >> 25988888

Success and failure of the cellular immune response against HIV-1.

Stephen A Migueles1, Mark Connors1.   

Abstract

The cellular immune response to HIV-1 has now been studied in extraordinary detail. A very large body of data provides the most likely reasons that the HIV-specific cellular immune response succeeds in a small number of people but fails in most. Understanding the success and failure of the HIV-specific cellular immune response has implications that extend not only to immunotherapies and vaccines for HIV-1 but also to the cellular immune response in other disease states. This Review focuses on the mechanisms that are most likely responsible for durable and potent immunologic control of HIV-1. Although we now have a detailed picture of the cellular immune responses to HIV-1, important questions remain regarding the nature of these responses and how they arise.

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Year:  2015        PMID： 25988888     DOI： 10.1038/ni.3161

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  116 in total

1.  Immunology. CD8 T cells remember with a little help.

Authors:  Susan M Kaech; Rafi Ahmed
Journal:  Science       Date:  2003-04-11       Impact factor: 47.728

2.  Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus.

Authors:  Karen A O'Connell; Timothy P Brennan; Justin R Bailey; Stuart C Ray; Robert F Siliciano; Joel N Blankson
Journal:  J Virol       Date:  2010-05-05       Impact factor: 5.103

3.  High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.

Authors:  Christoph T Berger; Nicole Frahm; David A Price; Beatriz Mothe; Musie Ghebremichael; Kari L Hartman; Leah M Henry; Jason M Brenchley; Laura E Ruff; Vanessa Venturi; Florencia Pereyra; John Sidney; Alessandro Sette; Daniel C Douek; Bruce D Walker; Daniel E Kaufmann; Christian Brander
Journal:  J Virol       Date:  2011-07-13       Impact factor: 5.103

4.  Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters.

Authors:  Florencia Pereyra; Sarah Palmer; Toshiyuki Miura; Brian L Block; Ann Wiegand; Alissa C Rothchild; Brett Baker; Rachel Rosenberg; Emily Cutrell; Michael S Seaman; John M Coffin; Bruce D Walker
Journal:  J Infect Dis       Date:  2009-09-15       Impact factor: 5.226

5.  HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication.

Authors:  Olivier Lambotte; Faroudy Boufassa; Yoann Madec; Ahn Nguyen; Cécile Goujard; Laurence Meyer; Christine Rouzioux; Alain Venet; Jean-François Delfraissy
Journal:  Clin Infect Dis       Date:  2005-08-30       Impact factor: 9.079

6.  Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.

Authors:  John W Shiver; Tong-Ming Fu; Ling Chen; Danilo R Casimiro; Mary-Ellen Davies; Robert K Evans; Zhi-Qiang Zhang; Adam J Simon; Wendy L Trigona; Sheri A Dubey; Lingyi Huang; Virginia A Harris; Romnie S Long; Xiaoping Liang; Larry Handt; William A Schleif; Lan Zhu; Daniel C Freed; Natasha V Persaud; Liming Guan; Kara S Punt; Aimin Tang; Minchun Chen; Keith A Wilson; Kelly B Collins; Gwendolyn J Heidecker; V Rose Fernandez; Helen C Perry; Joseph G Joyce; Karen M Grimm; James C Cook; Paul M Keller; Denise S Kresock; Henryk Mach; Robert D Troutman; Lynne A Isopi; Donna M Williams; Zheng Xu; Kathryn E Bohannon; David B Volkin; David C Montefiori; Ayako Miura; Georgia R Krivulka; Michelle A Lifton; Marcelo J Kuroda; Jörn E Schmitz; Norman L Letvin; Michael J Caulfield; Andrew J Bett; Rima Youil; David C Kaslow; Emilio A Emini
Journal:  Nature       Date:  2002-01-17       Impact factor: 49.962

7.  Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile.

Authors:  N L Haigwood; A Watson; W F Sutton; J McClure; A Lewis; J Ranchalis; B Travis; G Voss; N L Letvin; S L Hu; V M Hirsch; P R Johnson
Journal:  Immunol Lett       Date:  1996-06       Impact factor: 3.685

8.  Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.

Authors:  M Dean; M Carrington; C Winkler; G A Huttley; M W Smith; R Allikmets; J J Goedert; S P Buchbinder; E Vittinghoff; E Gomperts; S Donfield; D Vlahov; R Kaslow; A Saah; C Rinaldo; R Detels; S J O'Brien
Journal:  Science       Date:  1996-09-27       Impact factor: 47.728

9.  Phenotypic and functional separation of memory and effector human CD8+ T cells.

Authors:  D Hamann; P A Baars; M H Rep; B Hooibrink; S R Kerkhof-Garde; M R Klein; R A van Lier
Journal:  J Exp Med       Date:  1997-11-03       Impact factor: 14.307

10.  Immune clearance of highly pathogenic SIV infection.

Authors:  Scott G Hansen; Michael Piatak; Abigail B Ventura; Colette M Hughes; Roxanne M Gilbride; Julia C Ford; Kelli Oswald; Rebecca Shoemaker; Yuan Li; Matthew S Lewis; Awbrey N Gilliam; Guangwu Xu; Nathan Whizin; Benjamin J Burwitz; Shannon L Planer; John M Turner; Alfred W Legasse; Michael K Axthelm; Jay A Nelson; Klaus Früh; Jonah B Sacha; Jacob D Estes; Brandon F Keele; Paul T Edlefsen; Jeffrey D Lifson; Louis J Picker
Journal:  Nature       Date:  2013-09-11       Impact factor: 49.962
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  53 in total

1.  Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue.

Authors:  Marcus Buggert; Son Nguyen; Gonzalo Salgado-Montes de Oca; Bertram Bengsch; Samuel Darko; Amy Ransier; Emily R Roberts; Daniel Del Alcazar; Irene Bukh Brody; Laura A Vella; Lalit Beura; Sathi Wijeyesinghe; Ramin S Herati; Perla M Del Rio Estrada; Yuria Ablanedo-Terrazas; Leticia Kuri-Cervantes; Alberto Sada Japp; Sasikanth Manne; Shant Vartanian; Austin Huffman; Johan K Sandberg; Emma Gostick; Gregory Nadolski; Guido Silvestri; David H Canaday; David A Price; Constantinos Petrovas; Laura F Su; Golnaz Vahedi; Yoav Dori; Ian Frank; Maxim G Itkin; E John Wherry; Steven G Deeks; Ali Naji; Gustavo Reyes-Terán; David Masopust; Daniel C Douek; Michael R Betts
Journal:  Sci Immunol       Date:  2018-06-01

2.  Interferon Alpha Enhances NK Cell Function and the Suppressive Capacity of HIV-Specific CD8+ T Cells.

Authors:  Abena K R Kwaa; Chloe A G Talana; Joel N Blankson
Journal:  J Virol       Date:  2019-01-17       Impact factor: 5.103

3.  Immune Control of HIV.

Authors:  Muthukumar Balasubramaniam; Jui Pandhare; Chandravanu Dash
Journal:  J Life Sci (Westlake Village)       Date:  2019-06

Review 4.  Immunologic Control of HIV-1: What Have We Learned and Can We Induce It?

Authors:  Daniel C Rogan; Mark Connors
Journal:  Curr HIV/AIDS Rep       Date:  2021-03-11       Impact factor: 5.071

Review 5.  Immunotherapy against cancer-related viruses.

Authors:  Haruko Tashiro; Malcolm K Brenner
Journal:  Cell Res       Date:  2016-12-23       Impact factor: 25.617

6.  The Brief Case: Confirmed Positive HIV-1 Serologic Screening but Undetectable RNA Virus Load in a Pregnant Woman.

Authors:  Rohan P Joshi; Carlos A Gomez; David Steiner; Natali Aziz; Benjamin A Pinsky
Journal:  J Clin Microbiol       Date:  2017-12       Impact factor: 5.948

7.  T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable.

Authors:  Alok V Joglekar; Zhe Liu; Jeffrey K Weber; Yong Ouyang; John D Jeppson; Won Jun Noh; Pedro A Lamothe-Molina; Huabiao Chen; Seung-Gu Kang; Michael T Bethune; Ruhong Zhou; Bruce D Walker; David Baltimore
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-07       Impact factor: 11.205

8.  The gift of a lifetime: analysis of HIV at autopsy.

Authors:  Frank Maldarelli
Journal:  J Clin Invest       Date:  2020-04-01       Impact factor: 14.808

9.  Multiple Origins of Virus Persistence during Natural Control of HIV Infection.

Authors:  Eli A Boritz; Samuel Darko; Luke Swaszek; Gideon Wolf; David Wells; Xiaolin Wu; Amy R Henry; Farida Laboune; Jianfei Hu; David Ambrozak; Marybeth S Hughes; Rebecca Hoh; Joseph P Casazza; Alexander Vostal; Daniel Bunis; Krystelle Nganou-Makamdop; James S Lee; Stephen A Migueles; Richard A Koup; Mark Connors; Susan Moir; Timothy Schacker; Frank Maldarelli; Stephen H Hughes; Steven G Deeks; Daniel C Douek
Journal:  Cell       Date:  2016-07-21       Impact factor: 41.582

10.  Maintenance of HIV-Specific Memory B-Cell Responses in Elite Controllers Despite Low Viral Burdens.

Authors:  Clarisa M Buckner; Lela Kardava; Xiaozhen Zhang; Kathleen Gittens; J Shawn Justement; Colin Kovacs; Adrian B McDermott; Yuxing Li; Mohammad M Sajadi; Tae-Wook Chun; Anthony S Fauci; Susan Moir
Journal:  J Infect Dis       Date:  2016-04-27       Impact factor: 5.226
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