Literature DB >> 1064038

Different calcium requirements for proliferation of conditionally and unconditionally tumorigenic mouse cells.

A L Boynton, J F Whitfield.   

Abstract

Conditionally tumorigenic BALB/3T3 mouse cells (which produce tumors in BALB/c mice only under special conditions) cannot sustain DNA synthesis and consequently stop proliferating in media containing low concentrations (0-0.02 mM) of physiologically available calcium. By contrast, cells that have been neoplastically transformed (tumorigenic in mice without special assistance) in vitro by different oncogens, can sustain DNA synthesis and proliferate in such calcium-deficient media. The possible importance for tumor growth of an ability to withstand calcium deprivation is examined. It is suggested that this property may prove to be a reliable indicator of neoplastic transformation.

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Year:  1976        PMID： 1064038      PMCID： PMC430357          DOI： 10.1073/pnas.73.5.1651

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  38 in total

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Journal:  Am J Anat       Date:  1965-01

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Journal:  J Gen Microbiol       Date:  1961-05

3.  The control of immune response in vitro by Ca2+. II. The Ca2+-dependent period during mitogenic stimulation.

Authors:  T Diamantstein; A Ulmer
Journal:  Immunology       Date:  1975-01       Impact factor: 7.397

4.  Control of 3T3 cell proliferation by calcium.

Authors:  A L Boynton; J F Whitfield; R J Isaacs; H J Morton
Journal:  In Vitro       Date:  1974 Jul-Aug

5.  Microdetermination of calcium in biological material by automatic fluorometric titration.

Authors:  A B Borle; F N Briggs
Journal:  Anal Chem       Date:  1968-02       Impact factor: 6.986

6.  Calcium uptake during growth of Streptococcus lactis.

Authors:  A Hurst; W Lazarus
Journal:  Nature       Date:  1968-07-27       Impact factor: 49.962

7.  Stimulation by calcium of the entry of thymic lymphocytes into the deoxyribonucleic acid-synthetic (S) phase of the cell cycle.

Authors:  J F Whitfield; R H Rixon; A D Perris; T Youdale
Journal:  Exp Cell Res       Date:  1969-09       Impact factor: 3.905

8.  Calcium homeostasis and erythropoietic control in the rat.

Authors:  A D Perris; J F Whitfield
Journal:  Can J Physiol Pharmacol       Date:  1971-01       Impact factor: 2.273

9.  Malignant hemangioendotheliomas produced by subcutaneous inoculation of Balb/3T3 cells attached to glass beads.

Authors:  C W Boone
Journal:  Science       Date:  1975-04-04       Impact factor: 47.728

10.  Roles of calcium, serum, plasma, and folic acid in the control of proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts.

Authors:  S D Balk; J F Whitfield; T Youdale; A C Braun
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205
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  26 in total

1.  The reduced extracellular calcium requirement for proliferation by neoplastic hepatocytes.

Authors:  S H Swierenga; J F Whitfield; H P Morris
Journal:  In Vitro       Date:  1978-06

2.  Improved basal medium for Y-1 mouse adrenal cortex tumor cells in culture. I. Dependence of growth and steroid response on calcium ion concentration.

Authors:  L J Cuprak; C J Lammi; J I Crane
Journal:  In Vitro       Date:  1979-11

3.  Stimulation of sugar uptake and thymidine incorporation in mouse 3T3 cells by calcium phosphate and other extracellular particles.

Authors:  D W Barnes; S P Colowick
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

Review 4.  Calcium, cyclic AMP and protein kinase C--partners in mitogenesis.

Authors:  J F Whitfield; J P Durkin; D J Franks; L P Kleine; L Raptis; R H Rixon; M Sikorska; P R Walker
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

5.  Loss of proliferative calcium dependence: simple in vitro indicator of tumorigenicity.

Authors:  S H Swierenga; J F Whitfield; S Karasaki
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

6.  Calcium-activated K+ channels increase cell proliferation independent of K+ conductance.

Authors:  Joanne E Millership; Daniel C Devor; Kirk L Hamilton; Corina M Balut; Jason I E Bruce; Ian M Fearon
Journal:  Am J Physiol Cell Physiol       Date:  2010-12-01       Impact factor: 4.249

7.  Regulation of passive potassium transport of normal and transformed 3T3 mouse cell cultures by external calcium concentration and temperature.

Authors:  M Ernst; G Adam
Journal:  J Membr Biol       Date:  1981       Impact factor: 1.843

8.  Calmodulin antagonists decrease the binding of epidermal growth factor to transformed, but not to normal, human fibroblasts.

Authors:  P V Bodine; J T Tupper
Journal:  Biochem J       Date:  1984-03-01       Impact factor: 3.857

9.  Ca2+ and Mg2+ requirements for growth are not concomitantly reduced during cell transformation.

Authors:  S M Ribeiro; H A Armelin
Journal:  Mol Cell Biochem       Date:  1984       Impact factor: 3.396

10.  Chemical carcinogen-mouse mammary tumor virus interactions in cell transformation.

Authors:  D K Howard; J Schlom; P B Fisher
Journal:  In Vitro       Date:  1983-01
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