| Literature DB >> 1116866 |
Abstract
The Ca2+ requirement for stimulation of DNA synthesis in vitro by phytohaemagglutinin (PHA) and by lipopolysaccharide (LPS) was investigated using mouse spleen cells. During mitogenic stimulation two periods could be distinguished: a Ca2+-independent period which was followed by a Ca2+-dependent period. The results suggest that Ca2+ is required for a step preceeding DNA synthesis but not for the early initial phase of transformation.Entities:
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Year: 1975 PMID: 1116866 PMCID: PMC1445744
Source DB: PubMed Journal: Immunology ISSN: 0019-2805 Impact factor: 7.397