Literature DB >> 210108

The reduced extracellular calcium requirement for proliferation by neoplastic hepatocytes.

S H Swierenga, J F Whitfield, H P Morris.   

Abstract

Cells from neonatal rat livers were unable to maintain DNA-synthetic activity in calcium-deficient medium, but neoplastic hepatocytes from Morris hepatomas 5123 tc and 7795 synthesized DNA and proliferated indefinitely in this calcium-deficient medium. The calcium content of fresh hepatoma tissue from which these cultures were derived was as much as 10 times greater than that of normal liver; but this difference could not account for the insensitivity of neoplastic cells to extracellular calcium because it disappeared during subsequent cultivation in vitro.

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Year:  1978        PMID： 210108     DOI： 10.1007/bf02616095

Source DB:  PubMed          Journal:  In Vitro        ISSN： 0073-5655


  19 in total

1.  Studies on the persistence of differentiated functions in rat hepatocytes set into primary tissue cultures. Specific binding of 3H-bilirubin after eight days of staying in vitro.

Authors:  U Armato; E Draghi; P G Andreis
Journal:  Cell Differ       Date:  1975-06

2.  Studies in histochemistry. I. Determination of nucleic acids in microgram amounts of tissue.

Authors:  J F SCOTT; A P FRACCASTORO; E B TAFT
Journal:  J Histochem Cytochem       Date:  1956-01       Impact factor: 2.479

3.  Different extracellular calcium requirements for proliferation of nonneoplastic, preneoplastic, and neoplastic mouse cells.

Authors:  A L Boynton; J F Whitfield; R J Isaacs; R G Tremblay
Journal:  Cancer Res       Date:  1977-08       Impact factor: 12.701

4.  Calcium metabolism at the cellular level.

Authors:  A B Borle
Journal:  Fed Proc       Date:  1973-09

5.  The mineral content and water compartments of liver and of Morris hepatomata 5123tc and 3924A and the changes of composition occurring during necrosis in hepatoma 3924A.

Authors:  G D Van Rossum; T Galeotti; H P Morris
Journal:  Cancer Res       Date:  1973-05       Impact factor: 12.701

6.  Calcium and magnesium content of rat liver and Morris Hepatoma 5123 tc.

Authors:  R A Hickie; H Kalant
Journal:  Cancer Res       Date:  1967-06       Impact factor: 12.701

Review 7.  Studies on the development, biochemistry, and biology of experimental hepatomas.

Authors:  H P Morris
Journal:  Adv Cancer Res       Date:  1965       Impact factor: 6.242

Review 8.  The positive control of cell proliferation by the interplay on calcium ions and cyclic nucleotides. A review.

Authors:  J F Whitfield; J P MacManus; R H Rixon; A L Boynton; T Youdale; S Swierenga
Journal:  In Vitro       Date:  1976-01

9.  The control of liver regeneration by parathyroid hormone and calcium.

Authors:  R H Rixon; J F Whitfield
Journal:  J Cell Physiol       Date:  1975-12       Impact factor: 6.384

10.  Roles of calcium, serum, plasma, and folic acid in the control of proliferation of normal and Rous sarcoma virus-infected chicken fibroblasts.

Authors:  S D Balk; J F Whitfield; T Youdale; A C Braun
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205
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  4 in total

1.  Improved basal medium for Y-1 mouse adrenal cortex tumor cells in culture. I. Dependence of growth and steroid response on calcium ion concentration.

Authors:  L J Cuprak; C J Lammi; J I Crane
Journal:  In Vitro       Date:  1979-11

2.  Loss of proliferative calcium dependence: simple in vitro indicator of tumorigenicity.

Authors:  S H Swierenga; J F Whitfield; S Karasaki
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

Review 3.  The regulation of cell proliferation by calcium and cyclic AMP.

Authors:  J F Whitfield; A L Boynton; J P MacManus; M Sikorska; B K Tsang
Journal:  Mol Cell Biochem       Date:  1979-11-01       Impact factor: 3.396

4.  The modulation of growth of normal rat liver epithelial cells in calcium-poor medium by epidermal growth factor, phenobarbital, phorbol ester, and retinoic acid.

Authors:  M S Tsao; J D Smith; J W Grisham
Journal:  In Vitro Cell Dev Biol       Date:  1985-05
  4 in total

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