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Literature DB >> 10639477

Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.

M C Cruz¹, R A Sia, M Olson, G M Cox, J Heitman.

Abstract

The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.

Entities: Species

Mesh：

Substances：
Calcineurin

Year: 2000 PMID： 10639477 PMCID： PMC97236 DOI： 10.1128/IAI.68.2.982-985.2000

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

28 in total

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Journal: Genes Dev Date: 1999-04-01 Impact factor: 11.361

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Journal: Fungal Genet Biol Date: 1999-06 Impact factor: 3.495

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Journal: Antimicrob Agents Chemother Date: 2000-01 Impact factor: 5.191

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Journal: Infect Immun Date: 1989-09 Impact factor: 3.441

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Journal: Infect Immun Date: 1993-10 Impact factor: 3.441

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Journal: Proc Natl Acad Sci U S A Date: 1994-06-07 Impact factor: 11.205

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Authors: Y C Chang; K J Kwon-Chung
Journal: Mol Cell Biol Date: 1994-07 Impact factor: 4.272

10. Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.

Authors: T Nakamura; Y Liu; D Hirata; H Namba; S Harada; T Hirokawa; T Miyakawa
Journal: EMBO J Date: 1993-11 Impact factor: 11.598

39 in total

1. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.

Authors: William J Steinbach; Nina Singh; Jackie L Miller; Daniel K Benjamin; Wiley A Schell; Joseph Heitman; John R Perfect
Journal: Antimicrob Agents Chemother Date: 2004-12 Impact factor: 5.191

2. Calcineurin is required for Candida albicans to survive calcium stress in serum.

Authors: Jill R Blankenship; Joseph Heitman
Journal: Infect Immun Date: 2005-09 Impact factor: 3.441

Review 3. Calcineurin regulation in fungi and beyond.

Authors: Jamal Stie; Deborah Fox
Journal: Eukaryot Cell Date: 2007-12-07

4. Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.

Authors: Dimitrios P Kontoyiannis; Russell E Lewis; Barbara D Alexander; Olivier Lortholary; Françoise Dromer; Krishan L Gupta; George T John; Ramon Del Busto; Goran B Klintmalm; Jyoti Somani; G Marshall Lyon; Kenneth Pursell; Valentina Stosor; Patricia Munoz; Ajit P Limaye; Andre C Kalil; Timothy L Pruett; Julia Garcia-Diaz; Atul Humar; Sally Houston; Andrew A House; Dannah Wray; Susan Orloff; Lorraine A Dowdy; Robert A Fisher; Joseph Heitman; Nathaniel D Albert; Marilyn M Wagener; Nina Singh
Journal: Antimicrob Agents Chemother Date: 2007-12-10 Impact factor: 5.191

Review 5. Variability of phenotypic traits in Cryptococcus varieties and species and the resulting implications for pathogenesis.

Authors: Gunjan Gupta; Bettina C Fries
Journal: Future Microbiol Date: 2010-05 Impact factor: 3.165

Review 6. Signalling pathways in the pathogenesis of Cryptococcus.

Authors: Lukasz Kozubowski; Soo Chan Lee; Joseph Heitman
Journal: Cell Microbiol Date: 2008-12-19 Impact factor: 3.715

7. Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans.

Authors: Deborah S Fox; Gary M Cox; Joseph Heitman
Journal: Eukaryot Cell Date: 2003-10